| Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. | |
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MedLine Citation:
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PMID: 21622267 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Free radicals play an important role in cerebral ischemia-reperfusion injury. Accumulations of toxic free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only increase the susceptibility of brain tissue to ischemic damage but also trigger numerous molecular cascades, leading to increased blood-brain barrier (BBB) permeability, brain edema, hemorrhage and inflammation, and brain death. Activating matrix metalloproteinases (MMPs) is a key step in BBB disruption. MMPs are proteolytic zinc-containing enzymes responsible for degradation of the extracellular matrix around cerebral blood vessels and neurons. Free radicals can activate MMPs and subsequently induce the degradations of tight junctions (TJs), leading to BBB breakdown in cerebral ischemia-reperfusion injury. Recent studies revealed that caveolin-1, a membrane integral protein located at caveolae, can prevent the degradation of TJ proteins and protect the BBB integrity by inhibiting RNS production and MMPs activity. The interaction of caveolin-1 and RNS forms a positive feedback loop which provides amplified impacts on BBB dysfunction during cerebral ischemia-reperfusion injury. Here, we reviewed the recent progress in the interactions of RNS, caveolin-1 and MMPs. Current evidence indicates that the interactions of RNS, caveolin-1 and MMPs are critical signal pathways in BBB disruption and infarction enlargement during cerebral ischemia-reperfusion injury. |
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Authors:
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Yong Gu; Cathleen Michelle Dee; Jiangang Shen |
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Publication Detail:
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Type: Journal Article Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 3 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 1216-31 Citation Subset: IM |
Affiliation:
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School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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