Document Detail

Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats.
MedLine Citation:
PMID:  11883524     Owner:  NLM     Status:  MEDLINE    
Sodium valproate(VPA), ethosuximide(ESM), 200 mg/kg ip and flunarizine (FLU) 5 or 10 mg/kg ip were first administered independently to rats in order to study their effects on behavioural and EEG aspects of spike and wave discharges (SWDs) induced by y- hydroxybutyrate (GHB,100 mg/kg ip). GHB treated rats show behavioural changes and concomitant repetitive EEG episodes of 7 to 9 Hz SWDs, mimicking human absence seizures (AS), and can be used as a pharmacological model. The number and duration of SWDs were calculated for 1 hr from the EEG and were parameters for drug evaluation. VPA and ESM at 200 mg/kg, significantly reduced SWD number and duration/hr, while FLU showed significant reduction only at 10 but not at 5 mg/kg. Combination of FLU, 10 mg/kg with either VPA or ESM showed significant reduction of SWD number and duration, suggesting an additive effect of the anti-absence agents with the calcium channel blocker, FLU, on experimental absence seizures in rats.
K Subramanyam; J David; T Joseph
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  39     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  998-1001     Citation Subset:  IM    
Department of Pharmacology, St John's Medical College, Bangalore, India.
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MeSH Terms
Anticonvulsants / therapeutic use*
Calcium Channel Blockers / therapeutic use*
Disease Models, Animal
Drug Interactions
Drug Synergism
Epilepsy, Absence / chemically induced,  drug therapy*
Ethosuximide / therapeutic use*
Flunarizine / therapeutic use*
Rats, Wistar
Sodium Oxybate
Valproic Acid / therapeutic use*
Reg. No./Substance:
0/Anticonvulsants; 0/Calcium Channel Blockers; 502-85-2/Sodium Oxybate; 52468-60-7/Flunarizine; 77-67-8/Ethosuximide; 99-66-1/Valproic Acid

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