| Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats. | |
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MedLine Citation:
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PMID: 11883524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sodium valproate(VPA), ethosuximide(ESM), 200 mg/kg ip and flunarizine (FLU) 5 or 10 mg/kg ip were first administered independently to rats in order to study their effects on behavioural and EEG aspects of spike and wave discharges (SWDs) induced by y- hydroxybutyrate (GHB,100 mg/kg ip). GHB treated rats show behavioural changes and concomitant repetitive EEG episodes of 7 to 9 Hz SWDs, mimicking human absence seizures (AS), and can be used as a pharmacological model. The number and duration of SWDs were calculated for 1 hr from the EEG and were parameters for drug evaluation. VPA and ESM at 200 mg/kg, significantly reduced SWD number and duration/hr, while FLU showed significant reduction only at 10 but not at 5 mg/kg. Combination of FLU, 10 mg/kg with either VPA or ESM showed significant reduction of SWD number and duration, suggesting an additive effect of the anti-absence agents with the calcium channel blocker, FLU, on experimental absence seizures in rats. |
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Authors:
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K Subramanyam; J David; T Joseph |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 39 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-03-08 Completed Date: 2002-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 998-1001 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, St John's Medical College, Bangalore, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use* Calcium Channel Blockers / therapeutic use* Disease Models, Animal Drug Interactions Drug Synergism Electroencephalography Epilepsy, Absence / chemically induced, drug therapy* Ethosuximide / therapeutic use* Flunarizine / therapeutic use* Male Rats Rats, Wistar Sodium Oxybate Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Calcium Channel Blockers; 502-85-2/Sodium Oxybate; 52468-60-7/Flunarizine; 77-67-8/Ethosuximide; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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