Document Detail

Interaction of fibrinolysis and prothrombotic risk factors in neonates, infants and children with and without thromboembolism and underlying cardiac disease. a prospective study.
MedLine Citation:
PMID:  11457466     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Data of this study indicate that neonates and infants with underlying cardiac disease and basically increased PAI-1 due to the 4G/4G variant of the PAI-1 promoter polymorphism along with elevated t-PA levels in combination with further prothrombotic risk factors are at high risk of developing early thromboembolism during cardiac catheterisation.
U Nowak-Göttl; S Kotthoff; E Hagemeyer; R Junker; H G Kehl; H Vielhaber; D Kececioglu
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Thrombosis research     Volume:  103     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-12-04     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-101     Citation Subset:  IM    
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MeSH Terms
3' Untranslated Regions / genetics
Cardiac Catheterization / adverse effects*
Case-Control Studies
Catheterization, Central Venous / adverse effects
Catheters, Indwelling / adverse effects
Child, Preschool
Factor V / genetics
Gene Frequency
Genetic Predisposition to Disease
Germany / epidemiology
Heart Defects, Congenital / blood*,  surgery
Infant, Newborn
Lipoprotein(a) / genetics
Plasminogen Activator Inhibitor 1 / genetics,  physiology*
Polymorphism, Genetic
Promoter Regions, Genetic / genetics
Prospective Studies
Protein C Deficiency / epidemiology,  genetics
Prothrombin / genetics
Risk Factors
Thromboembolism / epidemiology*,  etiology
Thrombophilia / epidemiology*,  genetics
Tissue Plasminogen Activator / physiology*
Reg. No./Substance:
0/3' Untranslated Regions; 0/Lipoprotein(a); 0/Plasminogen Activator Inhibitor 1; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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