| Interaction of ethanol, prostacyclin, and aspirin in determining human platelet reactivity in vitro. | |
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MedLine Citation:
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PMID: 2840054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethanol partitions into cellular membranes and alters membrane-associated phenomena in numerous cell types. Since platelet aggregation and its inhibition by prostacyclin are mediated by membrane-associated receptors and enzymes, we examined the interaction of ethanol, prostacyclin, and aspirin on human platelet reactivity. Using platelet-rich plasma, we examined the effect of increasing concentrations of ethanol (0.05% to 1.0%) on the platelet-inhibitory effects of a submaximal dose (5 x 10(-10) M) of prostacyclin, the concomitant production of cyclic 3',5'-adenosine monophosphate (AMP), and the release of thromboxane A2. Ethanol alone had little effect on platelet aggregation induced by 5 micrograms/ml collagen; however, it potentiated the inhibitory effect of prostacyclin on platelet aggregation in a dose-dependent manner in the range of 0.05% to 1.0% ethanol. Whereas prostacyclin increased platelet cyclic AMP levels, ethanol had no further effect on cyclic AMP levels. Ethanol alone reduced thromboxane A2 generation, but this effect could not totally account for the observed interaction of ethanol and prostacyclin on aggregation, since aspirin did not totally abolish the interaction. The dose range in which the ethanol/prostacyclin/aspirin interactions occur encompasses the plasma levels of ethanol that may be achieved by the consumption of alcoholic beverages. The results may, in part, explain the dose-related physiological and pathological consequences of chronic alcohol consumption on the cardiovascular system. |
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Authors:
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J A Jakubowski; R Vaillancourt; D Deykin |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 8 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1988 Jul-Aug |
Date Detail:
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Created Date: 1988-08-18 Completed Date: 1988-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 436-41 Citation Subset: IM |
Affiliation:
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Department of Hemostasis Research, Boston Veterans Administration Medical Center, Massachusetts 02130. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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pharmacology* Blood Platelets / drug effects, metabolism Collagen / pharmacology Cyclic AMP / biosynthesis Dose-Response Relationship, Drug Drug Interactions Epoprostenol / pharmacology* Ethanol / pharmacology* Humans Platelet Aggregation / drug effects* Thromboxane A2 / metabolism |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol; 50-78-2/Aspirin; 57576-52-0/Thromboxane A2; 60-92-4/Cyclic AMP; 64-17-5/Ethanol; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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