| Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic fatty acid synthesis and metabolism of male chickens (Gallus domesticus). | |
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MedLine Citation:
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PMID: 11423386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study tested the hypothesis that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) antagonizes estrogen-induced hepatic lipid synthesis and metabolism in birds. Twenty immature male chickens (Gallus domesticus) were divided evenly into four groups: (1) vehicle control; (2) estrogen alone (1.0 mg/kg estradiol cypionate injected on three consecutive days); (3) TCDD alone (50 microg/kg injected on the fourth day); and (4) a combination of the estrogen and TCDD treatments. On day 14, liver samples were collected for quantitative fatty acid analysis by capillary gas chromatography. Birds treated with estrogen alone had increased total triacylglyceride concentrations with specific increases in the Delta9 desaturase products 16:1n7, 18:1n7, 18:1n9, and 20:1n9. In addition, estrogen treatment specifically increased 22:6n3 concentrations in both triacylglycerides and phospholipids. However, these increases in Delta9 desaturase products or 22:6n3 did not occur for birds treated with estrogen in combination with TCDD. TCDD and estrogen plus TCDD treatments increased phospholipid concentrations of the diet-derived polyunsaturated fatty acids 18:2n6, 18:3n6, 20:3n6, 18:3n3, and 20:5n3, although only the estrogen plus TCDD group had significantly increased total phospholipids. In cholesterol esters, all three treatments decreased concentrations of total fatty acids, saturated fatty acids, and Delta9 desaturase products compared to the control group. |
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Authors:
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B Stanton; S Watkins; J B German; B Lasley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Volume: 129 ISSN: 1532-0456 ISO Abbreviation: Comp. Biochem. Physiol. C Toxicol. Pharmacol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-25 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100959500 Medline TA: Comp Biochem Physiol C Toxicol Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 137-50 Citation Subset: IM |
Affiliation:
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Institute of Toxicology and Environmental Health (ITEH), University of California Davis, One Shields Ave., 95616, Davis, CA, USA. rjstanton@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens / metabolism* Chromatography, Gas Chromatography, Thin Layer Dose-Response Relationship, Drug Drug Antagonism Environmental Pollutants / pharmacology* Estrogen Antagonists / pharmacology* Fatty Acids / metabolism* Liver / drug effects, metabolism* Male Phospholipids / metabolism Tetrachlorodibenzodioxin / metabolism, pharmacology* Triglycerides / metabolism Wasting Syndrome / chemically induced, veterinary |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Estrogen Antagonists; 0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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