Document Detail

Interaction effects between total energy and macronutrient intakes and angiotensin-converting enzyme 1 ( ACE) I/D polymorphism on adiposity-related phenotypes in toddlers and preschoolers: the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers: the GENESIS study. [corrected]
MedLine Citation:
PMID:  18479585     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate the interaction between the angiotensin-converting enzyme 1 (ACE) I/D polymorphism and energy and macronutrient intakes on adiposity-related phenotypes among toddlers and preschoolers. A representative sample of 2374 Greek children aged 1 to 5 years old was examined (Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS)). Dietary and anthropometric (i.e. BMI, waist circumference (WC)) assessments were carried out using standard procedures. DNA samples were obtained from 2102 children and were genotyped for the ACE I/D polymorphism. Among the entire population, 17 % were 'at risk of overweight' and a similar percentage were 'overweight'. The frequencies of the II, ID and DD genotypes were 16, 46 and 38 %, respectively. Significant interactions were found between the ACE I/D polymorphism and total energy intake on WC (P = 0.004 for interaction) and the ACE I/D polymorphism and protein intake on BMI and being overweight (P < 0.05 for interaction). Furthermore, it was found that the ACE I/D polymorphism may modify the effect of fat intake on WC and BMI, but this interaction disappeared after adjustment for additional potential confounders. Stratified analyses revealed that total energy is correlated with WC and protein intake is associated with BMI and being overweight only among carriers of the D-allele (i.e. DD or ID genotypes). These results suggest that the ACE I/D polymorphism may act as a modifying factor in the response of adiposity-related phenotypes to diet.
Georgia Kourlaba; Yannis P Pitsiladis; Vasiliki Lagou; Evangelia Grammatikaki; Colin N Moran; Katerina Kondaki; Eleytheria Roma-Giannikou; Yannis Manios
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  100     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-30     Revised Date:  2009-12-22    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1333-40     Citation Subset:  IM    
Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, Kallithea 17671, Athens, Greece.
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MeSH Terms
Adiposity / genetics*,  physiology
Anthropometry / methods
Body Mass Index
Child Nutritional Physiological Phenomena / genetics*,  physiology
Child, Preschool
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Energy Intake / physiology*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Grant Support
//Biotechnology and Biological Sciences Research Council; //Medical Research Council
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; EC A
Erratum In:
Br J Nutr. 2009 Mar;101(5):774

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