Document Detail


Interaction of cytidine 5'-monophosphate with Au(111): an in situ infrared spectroscopic study.
MedLine Citation:
PMID:  19347916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of cytidine 5'-monophosphate (CMP) with gold surfaces is studied by means of in situ infrared spectroscopy and cyclic voltammetry at the Au(111)|aqueous solution interface. Similar to other nucleic acid components, cytidine 5'-monophosphate is chemisorbed on the surface at positive potentials, and the amount of adsorbed CMP increases with the potential. Subtractively normalized interfacial Fourier-transform infrared spectroscopy (SNIFTIRS) is used to identify the adsorbed and desorbed species. Upon electrochemical desorption, the molecules released in solution are unprotonated on the N3 atom. Striking similarities are found between the spectrum of adsorbed CMP and the solution spectrum of protonated CMP. The origin of such similarities is discussed. The results strongly suggest that chemisorption occurs through the N3 atom of the pyrimidine ring. A comparison is drawn with cytidine, whose electrochemical and spectroscopic behaviors are also investigated.
Authors:
Thomas Doneux; Lukás Fojt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemphyschem : a European journal of chemical physics and physical chemistry     Volume:  10     ISSN:  1439-7641     ISO Abbreviation:  Chemphyschem     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954211     Medline TA:  Chemphyschem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1649-55     Citation Subset:  IM    
Affiliation:
Institute of Biophysics ASCR v.v.i., Královopolská 135, 612 65 Brno, Czech Republic. tdoneux@ulb.ac.be
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MeSH Terms
Descriptor/Qualifier:
Cytidine Monophosphate / chemistry*
Gold / chemistry*
Potentiometry
Spectroscopy, Fourier Transform Infrared
Chemical
Reg. No./Substance:
63-37-6/Cytidine Monophosphate; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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