| Interaction of the conceptus and endometrium to establish pregnancy in mammals: role of interleukin 1β | |
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MedLine Citation:
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PMID: 22382391 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Implantation and the establishment of pregnancy in mammals involves an intricate interplay of hormones, cytokines, growth factors, proteins, lipids, ions and the extracellular matrix between the uterine epithelium, stroma, immune cells and the conceptus trophectoderm. The divergent nature of implantation in the mouse, human and pig provides not only an interesting contrast in the establishment of pregnancy and early embryonic development but also intriguing similarities with regard to early endometrial-conceptus signaling. An interesting pro-inflammatory cytokine expressed in a number of mammalian species during the period of implantation is interleukin-1β (IL1B). The presence of IL1B might be involved with immunotolerance at the maternal-placental interface and has been proposed as one of the mediators in placental viviparity. The production of IL1B and other proinflammatory cytokines might play a role in establishing pregnancy through modulation of the nuclear factor kappa-B (NFKB) system in a number of species. A model for the regulation of cellular progesterone receptor expression and NFKB activation for endometrial receptivity and conceptus attachment is continuing to evolve and is discussed in the present review. |
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Authors:
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Rodney Geisert; Asgerally Fazleabas; Mathew Lucy; Daniel Mathew |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-2 |
Journal Detail:
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Title: Cell and tissue research Volume: - ISSN: 1432-0878 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Animal Sciences, University of Missouri, Columbia, Mo., USA, geisertr@missouri.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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