| Interaction of commonly used emollients with photochemotherapy. | |
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MedLine Citation:
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PMID: 11019939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIM: Even though emollients are commonly used in combination with photochemotherapy, we still lack guidance for the selection of the appropriate emollient to be used in combination with photochemotherapy. The purpose of our study was to determine the interaction of commonly used emollients with photochemotherapy. METHODS: The study was carried on 75 healthy volunteers. In order to assess the effects of five different emollients--white petrolatum, 3% salicylic acid in white petrolatum, Balmandol, Decubal and Urederm hydro--the subjects were divided into five groups. Minimal phototoxic dose (MPD) was determined by irradiating two rows of six circular test fields on the back of the subjects with increasing doses of UVA. One of the emollients listed above was applied to the skin under the upper rows alternatively, whereas the lower rows served as control. RESULTS: Application of Urederm hydro and Decubal before exposure to UVA resulted in a statistically significant decrease in the MPD in all subjects. Even though application of white petrolatum and white petrolatum containing 3% salicylic acid decreased the MPD in most of the subjects and Balmandol application slightly increased the MPD, the results did not reach statistical significance. CONCLUSIONS: According to our findings, it is probable that the total dose of UVA needed to cause clearing of psoriasis would be decreased by application of Urederm hydro and Decubal prior to photochemotherapy. We noted a slight photoprotective effect of Balmandol in the UVA range, but this finding has to be further studied. Clinical studies are needed to clarify the effects of these emollients on the course and outcome of photochemotherapy. |
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Authors:
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A Boyvat; H Erdi; A Birol; E Gurgey |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 16 ISSN: 0905-4383 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2001-02-23 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: DENMARK |
Other Details:
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Languages: eng Pagination: 156-60 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Ankara University School of Medicine, Turkey. boyvat@dialup.ankara.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Emollients / pharmacology*, therapeutic use Erythema Female Humans Male PUVA Therapy Photochemotherapy* Psoriasis / drug therapy Skin Diseases / drug therapy Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Emollients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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