Document Detail


Interaction of carotid chemoreceptor and baroreceptor reflexes in anesthetized dogs.
MedLine Citation:
PMID:  3337264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interaction between baroreceptors and chemoreceptors during simultaneous activation of the reflexes was studied in eight pentobarbital sodium-anesthetized vagotomized dogs. The carotid sinus reflexogenic area was isolated and perfused at controlled carotid sinus pressure (CSP), PO2, and PCO2. Random combinations of CSP, PO2, and PCO2 were delivered to the carotid sinus. Results were analyzed by multiple linear regression. For the arterial pressure response, increasing CO2 resulted in an upward shift of the baroreceptor reflex response curve and an increased slope of the linear portion of the curve. The heart rate-CSP curve was also shifted upward by CO2, with the effect being greatest at high levels of CSP. The respiratory frequency-CO2 relationship had an increased slope and was shifted upward when CSP was decreased. The responses of tidal volume and ventilation (VE) depended on all three inputs. At any level of PO2, decreasing CSP resulted in a parallel shift of the VE-CO2 relationship. The results indicate that there is a significant interaction between chemoreceptor and baroreceptor reflex sensitivities.
Authors:
M J Brunner; A Wallace; C L MacAnespie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-25     Completed Date:  1988-02-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1-10     Citation Subset:  IM    
Affiliation:
Department of Physiology, Dental School, University of Maryland, Baltimore 21201.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Blood Pressure
Cardiovascular Physiological Phenomena
Carotid Sinus / physiology*
Chemoreceptor Cells / physiology*
Dogs
Heart Rate
Pressoreceptors / physiology*
Reference Values
Respiration
Grant Support
ID/Acronym/Agency:
GM-07309/GM/NIGMS NIH HHS; HL-13039/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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