Document Detail

Interaction of bradykinin and prostaglandin E1 on cardiac pressor reflex and sympathetic afferents.
MedLine Citation:
PMID:  3706568     Owner:  NLM     Status:  MEDLINE    
Bradykinin applied to the epicardium stimulates cardiac sympathetic afferents and evokes a reflex increase in arterial blood pressure. In anesthetized cats we examined the potentiation of these effects by prostaglandin E1 (PGE1) applied to the ventricular epicardium. We recorded cardiac afferent impulses from the second to the fifth left thoracic sympathetic rami. PGE1 (0.1 microgram/ml) alone had little effect on blood pressure, but it significantly increased the pressor response to bradykinin, and it reduced or abolished tachyphylaxis to repeated applications of bradykinin. Both mechanosensitive and chemosensitive sympathetic cardiac afferents were stimulated by bradykinin. Indomethacin (intravenous) caused a small reduction in the afferent response to bradykinin. Epicardial application of PGE1 significantly increased the response (magnitude and duration) of chemosensitive endings to bradykinin but not that of mechanosensitive endings; however, PGE1 abolished the tachyphylaxis of both chemosensitive and mechanosensitive endings to repeated applications of bradykinin. Because both bradykinin and prostaglandins are released in the ischemic myocardium, their interactive effect on cardiac sympathetic afferents could play a part in the sensory and reflex responses to myocardial ischemia.
T Nerdrum; D G Baker; H M Coleridge; J C Coleridge
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-16     Completed Date:  1986-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R815-22     Citation Subset:  IM; S    
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MeSH Terms
Action Potentials / drug effects
Alprostadil / pharmacology*
Blood Pressure / drug effects*
Bradykinin / pharmacology*
Drug Interactions
Heart / drug effects*
Indomethacin / pharmacology
Neurons, Afferent / drug effects*,  physiology
Nociceptors / physiology
Reflex / drug effects*
Stimulation, Chemical
Sympathetic Nervous System / cytology,  drug effects*,  physiology
Grant Support
Reg. No./Substance:
53-86-1/Indomethacin; 58-82-2/Bradykinin; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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