| Interaction of bisoprolol and procainamide in human cardiac impulse generation and conduction. | |
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MedLine Citation:
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PMID: 11527128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combined treatment of beta-adrenoceptor-blocking agents and class I antiarrhythmic drugs can potentially have profound and deleterious effects on cardiac impulse formation and conduction. We studied the effect of 5 mg of oral bisoprolol daily and 10 mg/kg of procainamide intravenously with programmed electrical stimulation of the heart in 10 patients with postinfarction ventricular tachyarrhythmias. Oral bisoprolol slowed sinus rhythm and atrioventricular nodal conduction; ventricular effective refractory periods were increased significantly after several days of oral bisoprolol treatment. Combined treatment of oral bisoprolol and intravenous procainamide did not produce clinically relevant changes in parameters of cardiac impulse formation and conduction. This study shows that combined use of bisoprolol and a class I antiarrhythmic drug appears to be safe in patients with ventricular tachyarrhythrhythmias late after myocardial infarction. |
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Authors:
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J M Verrostte; N M van Hemel; J H Kingma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 16 Suppl 5 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1990 |
Date Detail:
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Created Date: 2001-08-30 Completed Date: 2001-09-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: S193-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adrenergic beta-Antagonists / administration & dosage* Adult Aged Anti-Arrhythmia Agents / administration & dosage* Atrioventricular Node / drug effects, physiology Bisoprolol / administration & dosage* Drug Interactions Drug Therapy, Combination Electrocardiography / drug effects* Electrophysiologic Techniques, Cardiac / methods Heart Conduction System / drug effects* Humans Infusions, Intravenous Middle Aged Myocardial Infarction / drug therapy Procainamide / administration & dosage* Tachycardia, Ventricular / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 51-06-9/Procainamide; 66722-44-9/Bisoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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