Document Detail

Interaction of bilirubin with human lymphocytes and granulocytes--the effect on bilirubin metabolism.
MedLine Citation:
PMID:  3792964     Owner:  NLM     Status:  MEDLINE    
An in vitro degradation of bilirubin by isolated human granulocytes and lymphocytes is described. Changes in the bilirubin concentration during interaction with these cells were determined spectrophotometrically. The dependence of the reaction velocity on the original bilirubin concentration followed an adsorption isotherm, typical of enzyme processes with a Km of 79 microM at a cell concentration of 500/microL. The primary event is the adsorption of bilirubin to the cell surface and, in addition, its detoxication. Cyanide and sonic treatment of cells inhibit the reaction, salicylic acid enhances the cell activity. The bilirubin-detoxicating effect is discussed with respect to the therapy of hyperbilirubinaemia in neonates.
E Knobloch; I Miler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia microbiologica     Volume:  31     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
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MeSH Terms
Bilirubin / metabolism*
Granulocytes / drug effects,  immunology*
Lymphocytes / drug effects,  immunology*
Potassium Cyanide / pharmacology
Serum Albumin, Bovine / metabolism
Reg. No./Substance:
0/Serum Albumin, Bovine; 151-50-8/Potassium Cyanide; 635-65-4/Bilirubin

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