| Interaction between transient metabolically mediated dilatation and pressure induced constriction in the canine coronary artery. | |
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MedLine Citation:
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PMID: 10752548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study explored the interaction between metabolically mediated vasodilatation (ventricular extra-activation) and pressure induced vasoconstriction (transient augmentation of aortic diastolic pressure). Eight dogs having formalin-induced heart block were chronically instrumented with aortic and left ventricular catheters and an electromagnetic flow probe on the left circumflex coronary artery. At a heart rate of 60 beats/min a single ventricular extra-activation introduced at 200 ms after the normal paced beat resulted in a 13 +/- 1% decrease in diastolic coronary vascular resistance index (DCVRI) in the first response beat (D1) and a persistent vasodilatation lasting for five beats (D1-D5). An increase in aortic diastolic pressure (32 +/- 3% for 520 +/- 15 ms) resulted in 13 +/- 2% increase in DCVRI in the D1 which was not evident in subsequent beats. Following a combined intervention, DCVRI in D1 was not significantly different from control but DCVRI did decrease to a greater degree in the subsequent response beats (D2-D7). These data indicate that the responses of two opposing vasoactive stimuli, i.e., pressure induced vasoconstriction and metabolic vasodilatation, were negated in the first response beat. The metabolically mediated vasodilatation was unaltered in the subsequent response beats. |
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Authors:
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N Sadick; J C Rembert; J C Greenfield |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Basic research in cardiology Volume: 95 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-05-25 Completed Date: 2000-05-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 70-4 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / metabolism, physiology* Dogs Pressure Vascular Resistance Vasoconstriction / physiology* Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R37-18468//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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