| Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. | |
| | |
MedLine Citation:
|
PMID: 9112669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the comparative antithrombotic properties of LW 10082, acetylasalicylic acid (Aspisol), low molecular weight heparin (LMWH, CY 216) and sodium heparin using laser-induced thrombosis model. The animal model which has been used is well suited to observe platelet reactions to damaged endothelial cells and also to evaluate the effect of drugs on the formation of platelet thrombi. The rat mesenteric venules with a diameter of 20-30 microns were injured by well defined argon laser lesion. The number of laser injuries which were needed to induce a thrombus intermittently occluded the vessel was counted to quantitate the results. LW 10082 was injected sc 2 h prior to testing. The minimal effective dose of LW 10082 which significantly inhibited thrombus formation was 5 mg/kg. The antithrombotic effect of Aspisol has been investigated after its oral application at doses of 1.5 and 10 mg/kg 2 h before studying the antithrombotic effect. The minimal effective dose for Aspisol was 10 mg/kg. The LMWH has been injected into the rat tail vein in doses of 1, 0.2 and 0.1 mg/kg 30 min before testing. 0.1 mg/kg did not have any antithrombotic effect. The minimal effective dose of the sodium heparin which significantly inhibited thrombus formation was 20 U/kg measured 30 min after its iv injection. The combination of minimal effective dose of LW 10082 and LMWH had a significant additive effect. There was a slight but not significant additive effect between LW 10082, Aspisol and heparin sodium. Our results suggest that combinations of LW 10082 with LMWH may provide a new approach to more effective prophylaxis and treatment of venous or arterial thrombosis. |
| | |
Authors:
|
J Giedrojć; K Krupiński; H K Breddin; M Bielawiec |
Related Documents
:
|
15271419 - Tissue distribution of the low molecular weight heparin, tinzaparin, following administ... 17024039 - Intravenous nutrition: focus on delivery (3-in-1 bags or not?). 6648899 - Thrombin activity during hemodialysis; evaluated by the fibrinopeptide a assay. a compa... 8599189 - Anticoagulant effects of pseudechis australis (australian king brown snake) venom on hu... 7832299 - Platelet factor 4 injection produces acute pulmonary hypertension in the awake lamb. 1717609 - Activities of human acidic fibroblast growth factor in an in vitro dermal equivalent mo... 8032649 - The involvement of endothelial dysfunction, nitric oxide and prostanoids in the rat gas... 7947529 - Early abortion induction by a combination of mifepristone and oral misoprostol: a compa... 15144799 - A narrow time-window for access to the brain by exogenous protein after immunological t... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Polish journal of pharmacology Volume: 48 ISSN: 1230-6002 ISO Abbreviation: Pol J Pharmacol Publication Date: 1996 May-Jun |
Date Detail:
|
Created Date: 1997-06-27 Completed Date: 1997-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9313882 Medline TA: Pol J Pharmacol Country: POLAND |
Other Details:
|
Languages: eng Pagination: 317-22 Citation Subset: IM |
Affiliation:
|
Department of Haematology, Medical Academy, Białystok, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aspirin / therapeutic use Disaccharides / therapeutic use* Disease Models, Animal Dose-Response Relationship, Drug Drug Synergism Fibrinolytic Agents / therapeutic use* Heparin / therapeutic use Heparin, Low-Molecular-Weight / therapeutic use Lasers / adverse effects Male Rats Rats, Wistar Thrombophlebitis / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Disaccharides; 0/Fibrinolytic Agents; 0/Heparin, Low-Molecular-Weight; 123072-45-7/aprosulate; 50-78-2/Aspirin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endothelial and glial cell interaction in diabetic retinopathy via the function of vascular endothel...
Next Document: Effect of nonionic and ionic contrast media on fibrinolysis in patients undergoing angiography.