| Interaction between sexhormones and WNT/β-catenin signal transduction in endometrial physiology and disease. | |
| | |
MedLine Citation:
|
PMID: 21722706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Wnt/β-catenin signalling plays a rate-limiting role in early development of many different organs in a broad spectrum of organisms. In the developing Müllerian duct, Wnt/β-catenin signalling is important for initiation, outgrowth, patterning and differentiation into vagina, cervix, uterus and oviducts. In adult life, sex hormones modulate Wnt/β-catenin signalling in the endometrium to maintain the monthly balance between estrogen-induced proliferation and progesterone-induced differentiation, and enhanced Wnt/β-catenin signalling seems to be involved in endometrial carcinogenesis. However, early in pregnancy enhanced Wnt/β-catenin signalling is prerequisite for proper implantation and invasion of trophoblast cells into endometrium and myometrium thus helping to form a placenta. Overall, it seems that tight control of Wnt/β-catenin signalling in time and space is important for initiation, development and normal function of the female reproductive tract. However, if Wnt/β-catenin signalling is not kept in check, it easily seems to initiate or contribute to development of a number of uterine disorders. |
| | |
Authors:
|
Paul H van der Horst; Yongyi Wang; Marten van de Zee; Curt W Burger; Leen J Blok |
Related Documents
:
|
22200816 - Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expr... 21757716 - Rna-binding protein insulin-like growth factor mrna-binding protein 3 (imp-3) promotes ... 22112566 - Enhancing the recombinant protein expression of halohydrin dehalogenase hhea in escheri... 16223696 - Expression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinata... 19763736 - Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemi... 21179466 - Presenilin controls cbp levels in the adult drosophila central nervous system. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
|
Title: Molecular and cellular endocrinology Volume: - ISSN: 1872-8057 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-7-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Obstetrics and Gynaecology, Erasmus University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A needle in a haystack: Mutations in GNRH1 as a rare cause of isolated GnRH deficiency.
Next Document: Blood pressure increased dramatically in hypertensive rats after left hemisphere lesions with 6-hydr...