| Interaction between pesticides and essential metal copper increases the accumulation of copper in the kidneys of rats. | |
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MedLine Citation:
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PMID: 16327070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without or with a pesticides mixture (PM); Endosulfan, Thiram, and Acephate were added to the diets at 25% of LD50/kg. Rats were fed for 2 wk (small intestinal changes) or 4 wk (tissues changes). Plasma Zn was 47% lower than CON in the experimental groups. Plasma Cu and ceruloplasmin concomitantly decreased in the LC+Z+C group and increased with the addition of PM. Kidney Cu was 40% lower in LC+Z+C group, than CON and increased by 31% with PM; in the HZ+C+PM group, kidney Cu was 38% higher than the HZ+C group. Mucosal and small intestines Ca declined by 47% in all experimental groups; PM increased Zn in the LC+Z+C and HZ+C groups; PM further decreased intestinal and mucosal Cu retention in the LC+Z+C and HZ+C groups. Data suggest that low levels of PM in the diet can induce Cu accumulation in the kidney when dietary Zn and Cu are low or high. |
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Authors:
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Myna Panemangalore; Frederick N Bebe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 108 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 169-84 Citation Subset: IM |
Affiliation:
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Nutrition and Health Program, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / blood, metabolism Ceruloplasmin / metabolism Copper / blood, metabolism* Diet Kidney / drug effects*, enzymology, metabolism Male Pesticides / metabolism, pharmacology* Rats Rats, Sprague-Dawley Species Specificity Zinc / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Pesticides; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium; EC 1.16.3.1/Ceruloplasmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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