| Interaction between oral estrogen plus progestogen therapy and ABO blood groups on coagulation activation in postmenopausal women. | |
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MedLine Citation:
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PMID: 22089178 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: The aim of this study was to investigate the effect of postmenopausal hormone therapy on coagulation and whether this effect differs according to ABO blood groups. METHODS:: This was a prospective observational study to evaluate factor VIII (FVIII) activity, factor von Willebrand (vWF), and D-dimer (D-Di) levels and ABO blood groups in 61 postmenopausal women using oral estrogen plus progestogen therapy (EPT; 2 mg estradiol + 1 mg norethisterone acetate) for 3 months and in 101 women not using EPT. After 3 months, all eligible women who had completed the treatment scheme proposed for the EPT group or those who opted to participate but had not undergone EPT had a blood sample collected for analysis. RESULTS:: Significant differences were observed in FVIII activity and vWF levels in the control group between those carrying group O and non-group O blood. For EPT users, significant differences were observed for FVIII activity, vWF, and D-Di levels. After a multivariate regression analysis, FVIII activity and ABO blood groups were independently associated with vWF levels, whereas interaction between ABO blood groups and EPT were independently associated with FVIII activity. Besides diabetes, the ABO × EPT interaction was also noted to be independently associated with D-Di levels. CONCLUSIONS:: These findings suggest an interactive effect between oral EPT and non-O blood groups, contributing to the mechanism by which estrogen triggers the hypercoagulability state and increased risk for venous thrombosis in women undergoing oral EPT. |
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Authors:
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Daniela Amorim Melgaço Guimarães; Mariana Silva Dos Santos; Karina Braga Gomes; Johanna G van der Bom; Danyelle Romana Rios; Jarbas Cardoso; Romerson Martins Franco; George da Silva Teixeira; Luci Maria Sant'ana Dusse; Maria das Graças Carvalho; Ana Paula Fernandes |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: - ISSN: 1530-0374 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the 1Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of Pharmaceutical Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil; 3Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; 4Healthy Science Center, Federal University of São João Del Rey, Divinópolis, Minas Gerais, Brazil; and 5Maternity Otaviano Neves, Belo Horizonte, Minas Gerais, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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