Document Detail

Interaction between neurokinin A, VIP, prostanoids, and enteric nerves in regulation of duodenal function.
MedLine Citation:
PMID:  9655689     Owner:  NLM     Status:  MEDLINE    
Neurokinin A (NKA) induces duodenal motility and increases mucosal permeability and bicarbonate secretion in the in situ perfused duodenum in anesthetized rats. In the present study, the NKA-induced increase in mucosal permeability was potentiated by luminal perfusion with lidocaine and diminished by vasoactive intestinal peptide (VIP) but unaltered by elevated intraluminal pressure. Elevation of intraluminal pressure, however, potentiated the stimulatory effect of NKA on bicarbonate secretion. In contrast, the tachykinin decreased the rate of alkalinization in rats subjected to elevated intraluminal pressure and treated with indomethacin. Similarly, NKA partially inhibited the VIP-stimulated bicarbonate secretion. Luminal lidocaine did not affect the secretory response to NKA. The motility induced by NKA was unaffected by VIP or lidocaine but decreased by elevated intraluminal pressure. It is concluded that the NKA-induced increase in duodenal mucosal bicarbonate secretion is independent of neurons and possibly mediated by prostanoids. The increase in mucosal permeability in response to NKA may be suppressed by mucosal nerves, perhaps utilizing VIP as one of the transmitters.
A Hällgren; G Flemström; O Nylander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-25     Completed Date:  1998-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G95-103     Citation Subset:  IM    
Department of Physiology, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden.
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MeSH Terms
Analysis of Variance
Bicarbonates / metabolism
Chromium Radioisotopes / pharmacokinetics
Duodenum / drug effects,  innervation,  physiology*
Edetic Acid / pharmacokinetics
Gastrointestinal Motility / drug effects,  physiology*
Indomethacin / pharmacology
Infusions, Intravenous
Intestinal Absorption / drug effects,  physiology*
Intestinal Mucosa / drug effects,  physiology*
Lidocaine / administration & dosage,  pharmacology
Metabolic Clearance Rate
Muscle, Smooth / drug effects,  innervation,  physiology*
Neurokinin A / administration & dosage,  pharmacology*
Neurons / drug effects,  physiology
Prostaglandins / physiology*
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology
Vasoactive Intestinal Peptide / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Bicarbonates; 0/Chromium Radioisotopes; 0/Prostaglandins; 137-58-6/Lidocaine; 37221-79-7/Vasoactive Intestinal Peptide; 53-86-1/Indomethacin; 60-00-4/Edetic Acid; 86933-74-6/Neurokinin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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