Document Detail

Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli.
MedLine Citation:
PMID:  3017915     Owner:  NLM     Status:  MEDLINE    
In Escherichia coli, the products of several genes are required for septation, and the products of several others are required for the maintenance of the rod shape of the cells. We show here that the combination of certain mutations in a division gene (ftsI) with a specific mutation in one of the shape genes (rodA) could produce cells with normal shape and division, although separately these mutations led to a loss of the capacity to divide (ftsI) or to form normal rod-shaped cells (rodA). In contrast, combinations between other mutant alleles of these genes produced double mutants which had lost the capacity both to divide and to form rod-shaped cells. The mutual phenotypic correction observed within particular pairs of mutant genes suggests that the normal morphogenetic cycle of growth and division may require direct interaction between the two membrane proteins which are the products of these genes.
K J Begg; B G Spratt; W D Donachie
Related Documents :
23143685 - Improved gene ontology annotation for biofilm formation, filamentous growth, and phenot...
10781535 - A mutation in the corynebacterium glutamicum ltsa gene causes susceptibility to lysozym...
21335375 - Vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for veg...
22160855 - Comparative epigenetic analysis of oct4 regulatory region in ra-induced differentiated ...
15914635 - Phic31 integrase confers genomic integration and long-term transgene expression in rat ...
6304005 - Overproduction of escherichia coli replication proteins by the use of runaway-replicati...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  167     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-17     Completed Date:  1986-10-17     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1004-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bacterial Proteins / genetics,  physiology*
Cell Division
Escherichia coli / genetics,  physiology*,  ultrastructure
Genes, Bacterial
Hexosyltransferases / genetics,  physiology*
Membrane Proteins / genetics,  physiology*
Peptidoglycan Glycosyltransferase
Suppression, Genetic
Reg. No./Substance:
0/Bacterial Proteins; 0/Membrane Proteins; EC 2.4.1.-/Hexosyltransferases; EC Glycosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inconsistent differences between neutral detergent fiber and total dietary fiber values of fruits an...
Next Document:  Growth phase and ompR regulation of transcription of microcin B17 genes.