| Interaction between leptin and leisure-time physical activity and development of hypertension. | |
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MedLine Citation:
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PMID: 22017362 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective. The mechanisms by which overweight and physical inactivity lead to hypertension are complex. Leptin, an adipocyte-derived hormone, has been linked with hypertension. We wanted to investigate the relationship between leptin, physical activity and new-onset hypertension. Methods. The study was a prospective cohort study of 744 women and 367 men, who were normotensive in the third Copenhagen City Heart Study (CCHS) examination, performed 1991-94. Based on questionnaire items, the participants were divided into two groups with low (n = 674) and high (n = 437) levels of leisure-time physical activity, respectively. Results. Between the third and the fourth CCHS examination, performed 2001-03, 304 had developed hypertension, defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg or use of antihypertensive medication. In a logistic regression model, including age, sex, body mass index, SBP, DBP, level of physical activity and leptin, we found a significant interaction between leptin and level of physical activity with new-onset hypertension as outcome variable (p = 0.012). When we entered the interaction variables, effect of leptin with low level of physical activity and with high level of physical activity, respectively, in the original model, leptin predicted new-onset hypertension in participants with low level of physical activity [odds ratio (95% confidence interval): 1.16 (1.01-1.33) for one unit increase in log-transformed leptin levels, p = 0.038], but not in participants with high level of physical activity [0.88 (0.74-1.05), p = 0.15]. Conclusion. We found that leptin predicted new-onset hypertension but only in participants with low level of physical activity. |
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Authors:
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Camilla Asferg; Rasmus Møgelvang; Allan Flyvbjerg; Jan Frystyk; Jan S Jensen; Jacob L Marott; Merete Appleyard; Peter Schnohr; Gorm B Jensen; Jørgen Jeppesen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
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Title: Blood pressure Volume: - ISSN: 1651-1999 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Glostrup , Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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