Document Detail


Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women.
MedLine Citation:
PMID:  23020644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial vaginosis has been associated with genital HIV-1 shedding; however, the effect of specific vaginal bacterial species has not been assessed. We tested cervicovaginal lavage from HIV-1-seropositive women for common Lactobacillus species: L. crispatus, L. jensenii, and seven BV-associated species: BVAB1, BVAB2, BVAB3, Leptotrichia, Sneathia, Megasphaera, and Atopobium spp. using quantitative PCR. We used linear and Poisson regression to evaluate associations between vaginal bacteria and genital HIV-1 RNA and DNA. Specimens from 54 U.S. (310 visits) and 50 Kenyan women (137 visits) were evaluated. Controlling for plasma viral load, U.S. and Kenyan women had similar rates of HIV-1 RNA (19% of visits vs. 24%; IRR=0.95; 95% CI 0.61, 1.49) and DNA shedding (79% vs. 76%; IRR=0.90; 0.78, 1.05). At visits during antiretroviral therapy (ART), the likelihood of detection of HIV-1 RNA shedding was greater with BVAB3 (IRR=3.16; 95% CI 1.36, 7.32), Leptotrichia, or Sneathia (IRR=2.13; 1.02, 4.72), and less with L. jensenii (IRR=0.39; 0.18, 0.84). At visits without ART, only L. crispatus was associated with a lower likelihood of HIV-1 RNA detection (IRR=0.6; 0.40, 0.91). Vaginal Lactobacillus species were associated with lower risk of genital HIV-1 shedding, while the presence of certain BV-associated species may increase that risk.
Authors:
Caroline Mitchell; Jennifer E Balkus; David Fredricks; Congzhou Liu; Jennifer McKernan-Mullin; Lisa M Frenkel; Christina Mwachari; Amneris Luque; Susan E Cohn; Craig R Cohen; Robert Coombs; Jane Hitti
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-05
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-05     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
DNA, Viral / metabolism*
Female
HIV Infections / complications,  microbiology,  transmission,  virology*
HIV-1 / physiology*
Humans
Kenya
Lactobacillus*
Middle Aged
Prospective Studies
RNA, Viral / metabolism*
United States
Vagina / microbiology,  virology*
Vaginosis, Bacterial / complications,  microbiology,  virology*
Virus Shedding / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
1K08AI087969-0/AI/NIAID NIH HHS; 1R21AI080439-01/AI/NIAID NIH HHS; P01 HD40540/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/RNA, Viral
Comments/Corrections

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