| Interaction between hormone replacement therapy preparations and oral anticoagulant therapy. | |
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MedLine Citation:
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PMID: 12892692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is limited information regarding the interaction of hormone replacement therapy (HRT) and oral anticoagulants. Following the acute over-anticoagulation of two women shortly after the initiation of tibolone, we have undertaken a retrospective review of anticoagulated women to determine if the dose of oral anticoagulants and quality of anticoagulant control are affected by the introduction of HRT. We demonstrate that acute over-anticoagulation consistently occurs following the commencement of tibolone and requires anticoagulant dose modification to re-establish target international normalised ratio (INR). In contrast, non-tibolone HRT preparations do not consistently alter anticoagulant control or dose requirements. |
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Authors:
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L A McLintock; A Dykes; R C Tait; I D Walker |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 110 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2003-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 777-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Haematology, Glasgow Royal Infirmary, Macewen Building, Castle Street, Glasgow G4 0SF, Scotland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anticoagulants / administration & dosage, contraindications* Dose-Response Relationship, Drug Drug Interactions Estrogen Receptor Modulators / administration & dosage, contraindications* Female Hormone Replacement Therapy / contraindications* Humans International Normalized Ratio Norpregnenes / administration & dosage, contraindications* Phenindione / administration & dosage, contraindications Warfarin / administration & dosage, contraindications |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Estrogen Receptor Modulators; 0/Norpregnenes; 5630-53-5/tibolone; 81-81-2/Warfarin; 83-12-5/Phenindione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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