Document Detail

Interaction between histidine-rich glycoprotein and platelet factor 4 with dermatan sulfate and low-molecular-weight dermatan sulfate.
MedLine Citation:
PMID:  1554154     Owner:  NLM     Status:  MEDLINE    
There is a controversy about whether or not histidine-rich glycoprotein (HRG), the most abundant plasma protein with glycosaminoglycans-neutralizing capacity, is able to prevent the inhibition of human thrombin by heparin cofactor II (HC II) in the presence of dermatan sulfate (DS). The authors studied the interaction of DS and low molecular weight DS, in a purified system with HRG, platelet factor 4 (PF 4), and with HC II. Their results show that HRG, like PF 4, has an affinity, not only for heparin, but also for DS. However, this affinity seems very weak. In fact, HRG is 10 times less effective than PF 4 in neutralizing the 50% antithrombin activity of HC II in the presence of DS.
G Cella; G Boeri; G Saggiorato; R Paolini; G Luzzatto; V I Terribile
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Angiology     Volume:  43     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-24     Completed Date:  1992-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Institute of Medical Semeiotics, University of Padua, Medical School, Italy.
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MeSH Terms
Blood Proteins / pharmacology*
Dermatan Sulfate / pharmacology*
Drug Interactions
Glycoproteins / pharmacology*
Heparin Cofactor II / pharmacology
Molecular Weight
Platelet Factor 4 / pharmacology*
Proteins / pharmacology*
Thrombin / antagonists & inhibitors
Reg. No./Substance:
0/Blood Proteins; 0/Glycoproteins; 0/Proteins; 0/histidine-rich proteins; 24967-94-0/Dermatan Sulfate; 37270-94-3/Platelet Factor 4; 81604-65-1/Heparin Cofactor II; EC

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