| Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways. | |
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MedLine Citation:
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PMID: 21964962 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To explore interactions between smoking and CYP2A6 genotypes on type 2 diabetes (T2DM) as well as potential pathways for smoking in causing T2DM.Design: Cross-sectional study.Methods: 1344 smokers with complete date from a community-based T2DM survey in Guangzhou and Zhuhai of China from July 2006 to June 2007 were interviewed with a structured questionnaire about socio-demographic status and daily cigarette consumption. Serum glucose, insulin and cotinine were measured after an overnight fast. Subjects were genotyped for CYP2A6 and classified according to genotype into normal, intermediate, slow or poor nicotine metabolizers based on prior knowledge of CYP2A6 allele associations with nicotine C-oxidation rate. Abdominal obesity was defined as a waist-to-hip ratio (WHR) ≥0.90 for males or ≥0.85 for females. Type 2 diabetic patients (n=154) were diagnosed according to World Health Organization (WHO) 1999 criteria. Chi-square tests, multivariate Logistic regression models and a structure equation model were used in the present study.Results: Multivariate analysis indicted that, compared to light smoking, heavy smoking significantly increased the risk of T2DM (OR=1.75, 95% CI=1.01-3.05). There were significant interactions between heaviness of smoking and CYP2A6 slow (OR=5.12, 95% CI=1.08-24.23) and poor CYP2A6 metabolizer genotypes (OR=8.54, 95% CI=1.28-57.02) on T2DM. Structural equation modeling indicated that CYP2A6 moderation of smoking quantity risk on T2DM was mediated by effects on serum cotinine, abdominal obesity, insulin resistance and insulin secretion.Conclusions: Heavy smoking was significantly associated with T2DM, and this association was moderated by CYP2A6 genotype and mediated by serum cotinine, abdominal obesity, insulin resistance and insulin secretion. |
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Authors:
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Tao Liu; Weiqing Chen; Sean P David; Rachel F Tyndale; Hui Wang; Yu-Ming Chen; Xue-Qing Yu; Wei Chen; Qian Zhou; Wen-Hua Ling |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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T Liu, Department of Biostatistics and Epidemiology, Guangdong Provincial Key laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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