Document Detail

Interaction between ganglioside-containing liposome and rat T-lymphocyte: confocal fluorescence microscopic study.
MedLine Citation:
PMID:  7945325     Owner:  NLM     Status:  MEDLINE    
Interaction between rat T-lymphocytes and a ganglioside (GM3, GD3, GT1b, or GQ1b)-containing liposome was investigated in vitro. The direct stimulation of T cell by a ganglioside-containing liposome was followed by monitoring an increase in the intracellular calcium signal using a confocal laser fluorescence microscopic method. The GT1b- or GQ1b-containing liposome strongly stimulated the cell, while the GM3- or GD3-containing liposome showed much less effect. Free gangliosides did not stimulate the cell at all under the same condition. The extent of the stimulation depended on the surface density of GT1b on the liposome accompanied by a clear threshold concentration. The efficiency of this direct T cell stimulation with the ganglioside-containing liposome was closely related to the efficiency of the tumor growth suppression reported previously by ourselves.
E Kato; K Akiyoshi; T Furuno; M Nakanishi; A Kikuchi; K Kataoka; J Sunamoto
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  203     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-10-31     Completed Date:  1994-10-31     Revised Date:  2008-08-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1750-5     Citation Subset:  IM    
Division of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan.
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MeSH Terms
Aniline Compounds
Calcium / metabolism*
Cell Membrane / metabolism*
Fluorescent Dyes
G(M3) Ganglioside / metabolism
Gangliosides / metabolism
Liposomes / metabolism*
Lymph Nodes
Microscopy, Confocal / methods
Rats, Wistar
Signal Transduction
T-Lymphocytes / metabolism*
Reg. No./Substance:
0/Aniline Compounds; 0/Fluorescent Dyes; 0/G(M3) Ganglioside; 0/Gangliosides; 0/Liposomes; 0/Xanthenes; 121714-13-4/Fluo-3; 59247-13-1/trisialoganglioside GT1; 62010-37-1/ganglioside, GD3; 68652-37-9/GQ1b ganglioside; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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