| Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats. | |
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MedLine Citation:
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PMID: 1906647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both oxygen free radicals and excitatory amino acids have been implicated as important cellular toxins in ischemic brain. Recent in vitro studies suggest that there may be a mutual interaction between these two mediators. We explored the relation between oxygen free radicals and excitatory amino acids in the development of ischemic brain edema in vivo. Male Sprague-Dawley rats were treated with the free radical scavenger dimethylthiourea 1 hour before ischemia or with the excitotoxin antagonist MK-801 30 minutes before ischemia produced by occlusion of the middle cerebral artery. Groups of seven or eight animals were treated with vehicle, low-dose (375 mg/kg) dimethylthiourea, high-dose (750 mg/kg) dimethylthiourea, low-dose (0.5 mg/kg) MK-801, high-dose (2.0 mg/kg) MK-801, or both high-dose dimethylthiourea and low-dose MK-801. After 4 hours of ischemia, brain water content was determined. In eight vehicle-treated controls, mean +/- SEM water content of tissue in the center of the ischemic zone was 83.29 +/- 0.18%. A significant reduction of brain edema was observed in all drug-treated groups: for example, 50.2% (p less than 0.001) in the high-dose dimethylthiourea group, 53.7% (p less than 0.001) in the low-dose MK-801 group, and 66.4% (p less than 0.001) in the combined dimethylthiourea and MK-801 group. Combined treatment with dimethylthiourea and MK-801 provided no significant additive effect over that resulting from treatment with MK-801 alone.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S M Oh; A L Betz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 22 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-08-22 Completed Date: 1991-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 915-21 Citation Subset: IM |
Affiliation:
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Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109-0718. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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physiology* Animals Brain / metabolism Brain Edema / etiology* Brain Ischemia / complications* Dizocilpine Maleate / pharmacology Drug Interactions Free Radicals Male Neurotoxins / physiology* Oxygen / physiology* Potassium / metabolism Rats Rats, Inbred Strains Sodium / metabolism Thiourea / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Free Radicals; 0/Neurotoxins; 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea; 7440-09-7/Potassium; 7440-23-5/Sodium; 77086-22-7/Dizocilpine Maleate; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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