Document Detail

Interaction between epidermal growth factor and triamcinolone acetonide in mouse palatal mesenchymal cells in vitro.
MedLine Citation:
PMID:  3010916     Owner:  NLM     Status:  MEDLINE    
Palatal mesenchymal cells from mouse embryos (MEPM cells) had a high number of specific receptors for epidermal growth factor (EGF). At 37 degrees C, the number of high-affinity receptors (dissociation constant, Kd of 6.0 X 10(-10) M) was 2.0 X 10(5) per cell and of low-affinity receptors (Kd of 2.9 X 10(-9) M), 3.8 X 10(5) per cell. At 2 degrees C, a single class of receptors (Kd of 4.8 X 10(-9) M) was detected at 1.8 X 10(5) per cell. Triamcinolone acetonide, a potent cleft-palate-inducing agent, slightly inhibited the recovery of 125I-labelled EGF binding capacity in MEPM cells after down regulation of EGF receptors; it did not affect the binding properties of 125I-labelled EGF in these cells.
T Kukita; K Kurisu
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  31     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-05-30     Completed Date:  1986-05-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  D; IM    
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MeSH Terms
DNA / biosynthesis
Drug Interactions
Epidermal Growth Factor / metabolism*,  pharmacology
Mice, Inbred Strains
Palate / embryology,  metabolism*
Protein Binding / drug effects
Receptor, Epidermal Growth Factor
Receptors, Cell Surface / biosynthesis
Triamcinolone Acetonide / metabolism*,  pharmacology
Reg. No./Substance:
0/Receptors, Cell Surface; 62229-50-9/Epidermal Growth Factor; 76-25-5/Triamcinolone Acetonide; 9007-49-2/DNA; EC, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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