Document Detail

Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice.
MedLine Citation:
PMID:  8872509     Owner:  NLM     Status:  MEDLINE    
Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. The oral administration of nimesulide alone induced clonic convulsions at more than 300 mg/kg. The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. The combination of nimesulide at 200 mg/kg and enoxacin at 400 mg/kg induced no convulsion. In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. These results suggest that the combination of nimesulide and enoxacin may possibly induce few or less convulsions in the clinical setting.
Y Taniguchi; Y Deguchi; K Noda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  45     ISSN:  1023-3830     ISO Abbreviation:  Inflamm. Res.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-05-13     Completed Date:  1997-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  IM    
Tosu Research Laboratories, Hisamitsu Pharmaceutical Co. Inc., Saga, Japan.
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MeSH Terms
Anti-Infective Agents / toxicity*
Anti-Inflammatory Agents, Non-Steroidal / toxicity*
Drug Interactions
Enoxacin / toxicity*
Mice, Inbred Strains
Seizures / chemically induced*
Sulfonamides / toxicity*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 51803-78-2/nimesulide; 74011-58-8/Enoxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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