| Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. | |
| | |
MedLine Citation:
|
PMID: 19643819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Limited epidemiological evidence suggests that genetic polymorphisms of drug-metabolizing enzymes such as cytochrome P450 (CYP), glutathione S-transferase (GST) and N-acetyltransferase (NAT) may be involved in tobacco-related hepatocarcinogenesis. We conducted a case-control study, including 209 incident cases with hepatocellular carcinoma (HCC) and two different control groups [275 hospital controls and 381 patients with chronic liver disease (CLD) without HCC], to investigate whether CYP1A1, CYP1A2, CYP2A6, CYP2E1, GSTM1 and NAT2 polymorphisms are related to the risk of HCC with any interaction with cigarette smoking. Overall, no significant associations with HCC were observed for any genotypes against either control group. However, we found a significant interaction (P = 0.0045) between CYP1A2 -3860G>A polymorphism and current smoking on HCC risk when we compared HCC cases with CLD patients; adjusted odds ratios [ORs; and 95% confidence intervals (CIs)] for G/A and A/A genotypes relative to G/G genotype were 0.28 (0.12-0.66) and 0.18 (0.04-0.94), respectively, among current smokers (P trend = 0.002), as compared with 1.28 (0.80-2.06) and 0.76 (0.34-1.71), respectively, among never/former smokers (P trend = 0.96). Similarly, in CYP1A2 G/G genotype, significant risk increase was observed for current smoking (OR = 4.08, 95% CI = 2.02-8.25) or more recent cigarette use (e.g. pack-years during last 5 years, P trend = 0.0003) but not in G/A and A/A genotypes combined (OR for current smoking = 1.39, 95% CI = 0.63-3.03; P trend for pack-years during last 5 years = 0.40). These results suggest that the CYP1A2 -3860G>A polymorphism modifies the smoking-related HCC risk among CLD patients. |
| | |
Authors:
|
Takeshi Imaizumi; Yasuki Higaki; Megumi Hara; Tatsuhiko Sakamoto; Mikako Horita; Toshihiko Mizuta; Yuichiro Eguchi; Tsutomu Yasutake; Iwata Ozaki; Kyosuke Yamamoto; Shingo Onohara; Seiji Kawazoe; Hirohisa Shigematsu; Shunzo Koizumi; Sho Kudo; Keitaro Tanaka |
Related Documents
:
|
22911169 - Lifestyle factors associated with gastroesophageal reflux disease in the japanese popul... 22325679 - Current limitations in the management of cardiovascular risk in rheumatoid arthritis. 22814369 - The forgotten griever: a nationwide follow-up study of mortality subsequent to the deat... 22349159 - Inappropriate prescribing for the elderly-a modern epidemic? 22382259 - Population screening for abdominal aortic aneurysm: evaluating the evidence against scr... 22681419 - How socioeconomic status influences road traffic injuries and home injuries in rome. 20357989 - Major determinants of serum homocysteine concentrations in a korean population. 15692079 - Association of intentional changes in body weight with coronary heart disease event rat... 2440659 - Effects of chemical smokes on flora and fauna under field and laboratory exposures. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-30 |
Journal Detail:
|
Title: Carcinogenesis Volume: 30 ISSN: 1460-2180 ISO Abbreviation: Carcinogenesis Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-06 Completed Date: 2009-10-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: England |
Other Details:
|
Languages: eng Pagination: 1729-34 Citation Subset: IM |
Affiliation:
|
Department of Preventive Medicine, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine Adult Age Distribution Aged Carcinoma, Hepatocellular / epidemiology*, genetics* Cytochrome P-450 CYP1A1 / genetics Cytochrome P-450 CYP1A2 / genetics* Cytochrome P-450 Enzyme System / genetics Female Guanine Humans Incidence Japan / epidemiology Liver Diseases / epidemiology, genetics* Liver Neoplasms / epidemiology*, genetics* Male Middle Aged Odds Ratio Outpatients / statistics & numerical data Polymorphism, Genetic* Polymorphism, Single Nucleotide* Risk Factors Smoking / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/cytochrome P-450 CYP1A6 (fish); 73-24-5/Adenine; 73-40-5/Guanine; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 1.14.14.1/Cytochrome P-450 CYP1A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Seasonal increase in olfactory receptor neurons of the Japanese toad, Bufo japonicus, is paralleled ...
Next Document: The human homolog of the Drosophila headcase protein slows down cell division of head and neck cance...