| Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children. | |
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MedLine Citation:
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PMID: 12669678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Common variations in genes, such as apolipoprotein E (apo E) and cholesteryl ester transfer protein (CETP), are major determinants of plasma lipid and lipoprotein levels. As both apo E and CETP contribute to the reverse transport of cholesterol to the liver, the effects of variations at the CETP locus may very well interact with the apo E genotype. METHODS AND RESULTS: As part of an ongoing study, the combined effects of the apo E genotype and heterogeneity at the CETP gene locus on plasma lipids and lipoproteins were studied in a birth cohort sample of 257 Dutch prepubescent boys and girls (aged 6.7-8.1 years). The children with an apo E2E3 genotype (carrying the epsilon 2 allele; arg158-->cys) had lower concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) than those with an apo E4E3 (carrying the epsilon 4 allele; cys112-->arg) or apo E3E3 genotype (homozygous for the parent epsilon 3 allele). These associations were statistically significant in children who were homozygous (p = 0.004 for LDL; p = 0.002 for apo B) or heterozygous (p < 0.0001 for LDL and apo B) for the absence of the Taq-IB polymorphism at the CETP gene locus (B2 allele), but not in those homozygous for the presence of this variant (B1B1). The highest plasma high-density lipoprotein cholesterol (HDL-C) concentrations were observed in children with the CETP B2B2 genotype. The difference in HDL-C levels between the CETP genotype groups was statistically significant only in E2E3 carriers (p = 0.01). The LDL/HDL ratio was significantly lower in E2E3 carriers, but not when combined with a CETP B1B1 genotype. CONCLUSION: These findings indicate that the apo E genotype and heterogeneity at the CETP gene locus have an additive and interactive influence on plasma lipid and lipoprotein levels in children. |
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Authors:
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P Rump; R P Mensink; G Hornstra |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 12 ISSN: 0939-4753 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-04-02 Completed Date: 2003-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Italy |
Other Details:
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Languages: eng Pagination: 317-24 Citation Subset: IM |
Affiliation:
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Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, Maastricht, The Netherlands. p.rump@medgen.azg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Apolipoproteins E / genetics* Carrier Proteins / genetics* Child Cholesterol Ester Transfer Proteins Cholesterol, HDL / genetics, metabolism* Cholesterol, LDL / genetics, metabolism* Cohort Studies Coronary Disease / epidemiology, genetics* Female Genetic Predisposition to Disease* Genotype Glycoproteins* Humans Hyperlipidemias / epidemiology, genetics* Incidence Male Netherlands / epidemiology Polymorphism, Genetic* Probability Risk Assessment Sensitivity and Specificity Sex Distribution |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/CETP protein, human; 0/Carrier Proteins; 0/Cholesterol Ester Transfer Proteins; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Glycoproteins |
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