| Interaction between cigarette smoking and hepatitis B and C virus infection on the risk of liver cancer: a meta-analysis. | |
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MedLine Citation:
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PMID: 20447919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Chronic infection with hepatitis B (HBV) and C viruses (HCV) as well as cigarette smoking are established risk factors of hepatocellular carcinoma (HCC), but it is unclear whether an interaction exists between these factors in causing hepatocellular carcinogenesis. We conducted a meta-analysis to evaluate the interaction of HBV and HCV infection and cigarette smoking on the risk of HCC. METHODS: We systematically searched the PUBMED and the China National Knowledge Infrastructure databases. A total of 16 eligible publications were identified. Cigarette smoking and chronic HBV and HCV infections were dichotomized into present or absent. Additive (S) and multiplicative interaction indexes (V) between smoking and each of the two infections and their 95% confidence intervals (95% CI) were calculated for each study and then combined in a meta-analysis. RESULTS: We found a more than additive interaction between HBV infection and cigarette smoking (S=1.44; 95% CI, 1.00-2.06; nine studies) and a more than multiplicative interaction (V=1.60; 95% CI, 1.16-2.20; six studies) between HCV infection and cigarette smoking. No publication bias was detected. CONCLUSION: Smoking seems to interact with both HBV and HCV in determining HCC risk. A pooled analysis of individual subject data, with appropriate adjustment with other risk factors, is warranted to confirm these results. IMPACT: The results of this study imply the evidence of a synergistic effect between smoking and HBV or HCV infection on the risk of HCC. Thus, chronic carriers of HBV or HCV are recommended to avoid smoking. |
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Authors:
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Shu-Chun Chuang; Yuan-Chin Amy Lee; Mia Hashibe; Min Dai; Tongzhang Zheng; Paolo Boffetta |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-19 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 1261-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 AACR |
Affiliation:
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IARC, International Prevention Research Institute, 95 cours Lafayette, 69006 Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
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etiology*,
pathology Case-Control Studies Cohort Studies Hepacivirus / isolation & purification Hepatitis B / complications* Hepatitis B virus / isolation & purification Hepatitis C / complications* Humans Liver Neoplasms / etiology*, pathology Smoking / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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T32 CA009142-21A1/CA/NCI NIH HHS; T32 CA09142/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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