| Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 16199552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: APOE is the only gene that has been consistently replicated as a risk factor for late onset Alzheimer's disease. Several recent studies have identified linkage to chromosome 10 for both risk and age of onset, suggesting that this region harbours genes that influence the development of the disease. A recent study reported association between single nucleotide polymorphisms (SNPs) in the VR22 gene (CTNNA3) on chromosome 10 and plasma levels of Abeta42, an endophenotype related to Alzheimer's disease. OBJECTIVE: To assess whether polymorphisms in the VR22 gene are associated with Alzheimer's disease in a large sample of Alzheimer's disease families and an independent set of unrelated cases and controls. RESULTS: Several SNPs showed association in either the family based or case-control analyses (p<0.05). The most consistent findings were with SNP6, for which there was significant evidence of association in both the families and the unrelated cases and controls. Furthermore, there was evidence of significant interaction between APOE-4 and two of the VR22 SNPs, with the strongest evidence of association being concentrated in individuals carrying APOE-4. CONCLUSIONS: This study suggests that VR22 or a nearby gene influences susceptibility to Alzheimer's disease, and the effect is dependent on APOE status. |
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Authors:
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E R Martin; P G Bronson; Y-J Li; N Wall; R-H Chung; D E Schmechel; G Small; P-T Xu; J Bartlett; N Schnetz-Boutaud; J L Haines; J R Gilbert; M A Pericak-Vance |
Publication Detail:
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Type: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medical genetics Volume: 42 ISSN: 1468-6244 ISO Abbreviation: J. Med. Genet. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-03 Completed Date: 2006-07-24 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985087R Medline TA: J Med Genet Country: England |
Other Details:
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Languages: eng Pagination: 787-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / genetics* Apolipoproteins E / genetics* Female Genetic Predisposition to Disease* Humans Linkage Disequilibrium Male Polymorphism, Genetic* Polymorphism, Single Nucleotide alpha Catenin / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG021547/AG/NIA NIH HHS; R01 AG19757/AG/NIA NIH HHS; R01 AG20135/AG/NIA NIH HHS; R01 NS31153/NS/NINDS NIH HHS; RR 00095/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/CTNNA3 protein, human; 0/alpha Catenin |
| Comments/Corrections | |
Comment In:
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J Med Genet. 2007 Jan;44(1):e63
[PMID:
17209133
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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