Document Detail

Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells.
MedLine Citation:
PMID:  21636775     Owner:  NLM     Status:  MEDLINE    
A blood cell type termed crystal cell in Drosophila functions in clotting and wound healing and requires Notch for specification and maintenance. We report that crystal cells express elevated levels of Sima protein orthologous to mammalian hypoxia-inducible factor-α (Hif-α) even under conditions of normal oxygen availability. In these platelet-like crystal cells, Sima activates full-length Notch receptor signaling via a noncanonical, ligand-independent mechanism that promotes hemocyte survival during both normal hematopoietic development and hypoxic stress. This interaction initiates in early endosomes, is independent of Hif-β (Τangο in Drosophila), and does not activate hypoxia response targets. Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-α protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-α/Notch interaction that may be conserved in mammals.
Tina Mukherjee; William Sang Kim; Lolitika Mandal; Utpal Banerjee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  332     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-03     Completed Date:  2011-06-21     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1210-3     Citation Subset:  IM    
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MeSH Terms
Aryl Hydrocarbon Receptor Nuclear Translocator / chemistry,  genetics,  metabolism
Calcium-Binding Proteins / metabolism
Cell Hypoxia
Cell Survival
Cytoplasmic Vesicles / metabolism
DNA-Binding Proteins / chemistry,  genetics,  metabolism*
Drosophila / cytology*,  genetics,  metabolism
Drosophila Proteins / chemistry,  genetics,  metabolism*
Hemocytes / cytology*,  physiology*
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Intercellular Signaling Peptides and Proteins / metabolism
Membrane Proteins / metabolism
Receptors, Notch / metabolism*
Signal Transduction
Stress, Physiological
Grant Support
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Intercellular Signaling Peptides and Proteins; 0/Ligands; 0/Membrane Proteins; 0/Receptors, Notch; 0/Sima protein, Drosophila; 0/notch protein, Drosophila; 0/tango protein, Drosophila; 134324-36-0/Serrate proteins; 138391-32-9/Aryl Hydrocarbon Receptor Nuclear Translocator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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