Document Detail

Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
MedLine Citation:
PMID:  19900416     Owner:  NLM     Status:  MEDLINE    
The role of nitric oxide (NO) in the activation-flow coupling (AFC) response to periodic electrical forepaw stimulation was investigated using signal averaged laser Doppler (LD) flowmetry. LD measures of calculated cerebral blood flow (CBF) were obtained both prior and after intra-peritoneal administration of the non-selective nitric oxide synthase (NOS) inhibitor, N(G)-nitro-L-arginine (L-NNA) (40 mg/kg). Characteristic baseline low frequency vasomotion oscillations (0.17 Hz) were observed after L-NNA administration. These LD(CBF) oscillations were synchronous within but not between hemispheres. L-NNA reduced the magnitude of the AFC response (p<0.05) for longer stimuli (1 min) with longer inter-stimulus intervals (2 min). In contrast, the magnitude of the AFC response for short duration stimuli (4 s) with short inter-stimulus intervals (20 s) was augmented (p<0.05) after L-NNA. An interaction occurred between L-NNA induced vasomotion oscillations and the AFC response with the greatest increase occurring at the stimulus harmonic closest to the oscillatory frequency. Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response.
Beau M Ances; Joel H Greenberg; John A Detre
Related Documents :
24344136 - Quantitative aspects of cgmp phosphodiesterase activation in carp rods and cones.
21725706 - Integrating multiple cues to depth order at object boundaries.
22105336 - Perceived size change induced by audiovisual temporal delays.
22013576 - Noise levels in adult and pediatric orthopedic cast clinics.
9428526 - Light-induced resetting of a mammalian circadian clock is associated with rapid inducti...
24695176 - Contrast-contrast asynchronies.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-10
Journal Detail:
Title:  Brain research     Volume:  1309     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-26     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-28     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Afferent Pathways / drug effects,  physiology
Biological Clocks / drug effects,  physiology*
Cerebral Arteries / drug effects,  physiology*
Cerebrovascular Circulation / drug effects,  physiology*
Electric Stimulation
Enzyme Inhibitors / pharmacology
Laser-Doppler Flowmetry
Nitric Oxide / metabolism*
Nitric Oxide Synthase Type I / antagonists & inhibitors,  metabolism*
Nitroarginine / pharmacology
Rats, Sprague-Dawley
Somatosensory Cortex / blood supply,  drug effects,  physiology*
Time Factors
Vasodilation / drug effects,  physiology
Vasodilator Agents / metabolism,  pharmacology
Vasomotor System / drug effects,  physiology
Grant Support
1K23 MH 081786/MH/NIMH NIH HHS; K23 MH081786/MH/NIMH NIH HHS; K23 MH081786-01/MH/NIMH NIH HHS; K23 MH081786-02/MH/NIMH NIH HHS; K23 MH081786-03/MH/NIMH NIH HHS
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Vasodilator Agents; 2149-70-4/Nitroarginine; 31C4KY9ESH/Nitric Oxide; EC Oxide Synthase Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biomolecular response of oxanine in DNA strands to T4 polynucleotide kinase, T4 DNA ligase, and rest...
Next Document:  Molecular and genetic substrates linking stress and addiction.