| Interaction between Gregg's phenomenon and coronary flow control: a model study. | |
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MedLine Citation:
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PMID: 10723882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary perfusion pressure, Pp, affects coronary arterial resistance, Ra, (autoregulation) as well as myocardial oxygen consumption, MVO2 (Gregg's phenomenon). The interaction between the effects of Pp and MVO2 on coronary flow control was investigated using a coronary flow control model. Model analysis predicts that response of the pressure-flow ratio, p/q(t), following a change in Pp depends on the sensitivity of Ra to a change in tissue oxygen concentration (tone sensitivity) and on the sensitivity of MVO2 to a change in capillary pressure (Gregg's sensitivity). At high tone sensitivity Gregg's effect is small, whereas at high Gregg's sensitivity autoregulation is attenuated. In experiments glibenclamide decelerated the p/q(t) in response to a pressure step by a factor of four. However, the proposed model demonstrates that this is compatible with a reduction in rate of change of Ra by a factor of ten. This is due to the interaction of negative and positive feedback gains in the model. Model analysis demonstrates that autoregulation and Gregg's phenomenon compete with each other in controlling coronary flow. |
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Authors:
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J Dankelman; H G Stassen; J A Spaan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical & biological engineering & computing Volume: 37 ISSN: 0140-0118 ISO Abbreviation: Med Biol Eng Comput Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-03-27 Completed Date: 2000-03-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7704869 Medline TA: Med Biol Eng Comput Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 742-9 Citation Subset: IM |
Affiliation:
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Man-Machine Systems and Control Group, Faculty of Design, Engineering and Production, Delft University of Technology, The Netherlands. j.dankelman@wbmt.tudelft.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / physiology* Goats Homeostasis / physiology* Models, Cardiovascular* Myocardium / metabolism Oxygen Consumption / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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