Document Detail


Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage.
MedLine Citation:
PMID:  21428875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several peptides are produced and released from endocrine cells scattered within the gastric oxyntic and the small intestinal mucosa. These peptide hormones are crucially involved in the regulation of gastrointestinal functions and food intake by conveying their information to central regulatory sites located in the brainstem as well as in the forebrain, such as hypothalamic nuclei. So far, ghrelin is the only known hormone that is peripherally produced in gastric X/A-like cells and centrally acting to stimulate food intake, whereas the suppression of feeding seems to be much more redundantly controlled by a number of gut peptides. Cholecystokinin produced in the duodenum is a well established anorexigenic hormone that interacts with ghrelin to modulate food intake indicating a regulatory network located at the first site of contact with nutrients in the stomach and upper small intestine. In addition, a number of peptides including leptin, urocortin 2, amylin and glucagon-like peptide 1 interact synergistically with CCK to potentiate its satiety signaling effect. New developments have led to the identification of additional peptides in X/A-like cells either derived from the pro-ghrelin gene by alternative splicing and posttranslational processing (obestatin) or a distinct gene (nucleobindin2/nesfatin-1) which have been investigated for their influence on food intake.
Authors:
Andreas Stengel; Yvette Taché
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current protein & peptide science     Volume:  12     ISSN:  1875-5550     ISO Abbreviation:  Curr. Protein Pept. Sci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-10-25     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  100960529     Medline TA:  Curr Protein Pept Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  293-304     Citation Subset:  IM    
Affiliation:
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholecystokinin / metabolism*,  pharmacology*
Eating / drug effects
Gastrointestinal Hormones / metabolism,  pharmacology*
Ghrelin / metabolism*,  pharmacology*
Humans
Hunger / drug effects*
Satiety Response / drug effects*
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; R01 DK033061/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Ghrelin; 9011-97-6/Cholecystokinin
Comments/Corrections

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