Document Detail


Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort.
MedLine Citation:
PMID:  17053541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: CYP1A1, one of the key enzymes in detoxifying toxic components produced during cigarette smoking, is regulated by aromatic hydrocarbon receptor (AHR). A CYP1A1 T3801C polymorphism, associated with a higher CYP1A1 inducibility and enhanced catalytic activity, has been linked to stroke, triple vessel disease and may, therefore, be associated with blood pressure (BP). The relation of the widely studied G1661A polymorphism of the human AHR gene with BP is unknown. OBJECTIVES: To investigate the genetic influence of CYP1A1 T3801C and AHR G1661A polymorphisms on BP in relation to tobacco consumption. DESIGN AND PARTICIPANTS: Study participants were selected from a French longitudinal cohort of volunteers for a free health check-up. These individuals (302 men and 311 women) were not taking medication that can affect blood pressure. Information about active smoking status was obtained by a self-administered questionnaire. RESULTS: After multiple regression analysis, systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not differ significantly according to their tobacco status excepted for DBP in men. In addition, neither CYP1A1 T3801C nor AHR G1661A polymorphism was linked to blood pressure. However, systolic and diastolic blood pressures differed significantly according to CYP1A1 T3801C genotype between ex-smokers and smokers. Finally, the interaction between CYP1A1 T3801C and AHR G1661A polymorphisms explained a significant difference of SBP and DBP between carriers of both CYP1A1-C3801 and AHR-A1661 alleles. CONCLUSION: This study is the first to show an interaction between the CYP1A1 T3801C and AHR G1661A polymorphisms. This interaction could explain the difference in blood pressure level between smokers and non-smokers/ex-smokers but needs to be confirmed in a large sample.
Authors:
Nicolas Gambier; Jean-Brice Marteau; Anne-Marie Batt; Bérangère Marie; Annick Thompson; Gérard Siest; Dorothee Foernzler; Sophie Visvikis-Siest
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2199-205     Citation Subset:  IM    
Affiliation:
INSERM U525, Faculté de Pharmacie, Université Henri Poincaré Nancy 1, Nancy, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects,  genetics*
Cohort Studies
Cytochrome P-450 CYP1A1 / genetics*
Female
Humans
Hypertension / genetics
Male
Middle Aged
Polymorphism, Genetic*
Receptors, Aryl Hydrocarbon / genetics*
Smoking / adverse effects*,  genetics
Chemical
Reg. No./Substance:
0/AHR protein, human; 0/Receptors, Aryl Hydrocarbon; EC 1.14.14.1/Cytochrome P-450 CYP1A1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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