Document Detail


Interaction between 2N-methyl-9-hydroxyellipticinium and ionizing radiation in CHO cells.
MedLine Citation:
PMID:  8103546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Incubation with 2N-methyl-9-hydroxyellipticinium (NMHE) increases the killing of gamma-irradiated CHO cells. The main effect is observed in the case of exponentially growing cells which are also more sensitive to the drug alone than plateau phase cells. Radiosensitivity increases with drug concentration and incubation time in the presence of the drug until a plateau value. However, the presence of NMHE in the culture medium inhibits neither the repair of sublethal nor potentially lethal damage. The influence of different ellipticine derivatives on the cell radiosensitivity was measured. The results show that only the hydroxylated derivatives (NMHE and 9-hydroxyellipticinium), which covalently bind to nucleic acids, increase the cellular sensitivity to ionizing radiations, whereas the non-hydroxylated derivative, 2N-methyl-ellipticinium, has no influence on cell radiosensitivity.
Authors:
F Laval
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation biology     Volume:  64     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-06     Completed Date:  1993-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  217-23     Citation Subset:  IM; S    
Affiliation:
U 247 INSERM, Institut Gustave Roussy, Villejuif, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells / radiation effects*
Cell Survival / radiation effects*
Cricetinae
DNA Damage / drug effects
Ellipticines / pharmacology*
Gamma Rays
Intercalating Agents
Radiation Dosage
Time Factors
Chemical
Reg. No./Substance:
0/Ellipticines; 0/Intercalating Agents; 58337-34-1/elliptinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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