| Interaction between 2N-methyl-9-hydroxyellipticinium and ionizing radiation in CHO cells. | |
| | |
MedLine Citation:
|
PMID: 8103546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Incubation with 2N-methyl-9-hydroxyellipticinium (NMHE) increases the killing of gamma-irradiated CHO cells. The main effect is observed in the case of exponentially growing cells which are also more sensitive to the drug alone than plateau phase cells. Radiosensitivity increases with drug concentration and incubation time in the presence of the drug until a plateau value. However, the presence of NMHE in the culture medium inhibits neither the repair of sublethal nor potentially lethal damage. The influence of different ellipticine derivatives on the cell radiosensitivity was measured. The results show that only the hydroxylated derivatives (NMHE and 9-hydroxyellipticinium), which covalently bind to nucleic acids, increase the cellular sensitivity to ionizing radiations, whereas the non-hydroxylated derivative, 2N-methyl-ellipticinium, has no influence on cell radiosensitivity. |
| | |
Authors:
|
F Laval |
Related Documents
:
|
17051156 - Glioma stem cells promote radioresistance by preferential activation of the dna damage ... 20211676 - Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective eff... 16210786 - Involvement of peroxiredoxin i in protecting cells from radiation-induced death. 1531976 - Modification of alkylating agent induced cell kill by 2-nitroimidazoles in unclamped an... 22450746 - Autocrine il-1β-traf6 signalling promotes squamous cell carcinoma invasion through par... 19389346 - Bax-mediated cell death affects early germ cell loss and incidence of testicular terato... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of radiation biology Volume: 64 ISSN: 0955-3002 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 1993 Aug |
Date Detail:
|
Created Date: 1993-10-06 Completed Date: 1993-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 217-23 Citation Subset: IM; S |
Affiliation:
|
U 247 INSERM, Institut Gustave Roussy, Villejuif, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals CHO Cells / radiation effects* Cell Survival / radiation effects* Cricetinae DNA Damage / drug effects Ellipticines / pharmacology* Gamma Rays Intercalating Agents Radiation Dosage Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Ellipticines; 0/Intercalating Agents; 58337-34-1/elliptinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targets for radiation-induced cell death: target replication during the cell cycle evaluated in cell...
Next Document: Thermal radiosensitization in heat- and radiation-sensitive mutants of CHO cells.