| Interaction of atrial natriuretic factor and angiotensin II in proximal HCO3- reabsorption. | |
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MedLine Citation:
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PMID: 1531734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bicarbonate reabsorption was evaluated by the acidification kinetics technique in middle proximal tubule in Munich-Wistar rats. Atrial natriuretic factor (ANF) and angiotensin II (ANG II) were infused into the jugular vein (ANF, 0.5 microgram.min-1.kg-1 after a prime of 10 micrograms/kg; ANG II, 20 ng.min-1.kg-1) or added to luminal or peritubular perfusion fluid (10(-6) M ANF; 10(-12) M ANG II). In the presence of ANF, in each condition, no significant differences in net HCO3- reabsorption or in acidification half time were observed compared with the control group. In the presence of ANG II, a significant increase in HCO3- reabsorption was observed, expressed by a fall in acidification half time from a mean of 4.75 +/- 0.20 (n = 86) to 2.47 +/- 0.18 s (n = 32) in systemically infused rats or to 2.30 +/- 0.15 s (n = 35) in luminally perfused tubules and from 4.57 +/- 0.32 (n = 44) to 2.04 +/- 0.10 s (n = 50) during capillary perfusion. However, when ANG II was systemically infused or perfused in lumen or in peritubular capillaries, addition of ANF to lumen or capillaries by perfusion or systemic infusion abolished the effects observed with ANG II alone. These studies confirm that ANG II stimulates proximal HCO3- reabsorption and show that ANF alone does not affect this process, but impairs the stimulation caused by ANG II. |
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Authors:
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G N Gomes; M M Aires |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-04-01 Completed Date: 1992-04-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: F303-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Escola Paulista de Medicina, Universidade de São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Acids / metabolism Angiotensin II / pharmacology* Animals Atrial Natriuretic Factor / pharmacology* Bicarbonates / pharmacokinetics* Drug Interactions Kidney Tubules, Proximal / metabolism* Male Perfusion Rats Rats, Inbred Strains Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Bicarbonates; 11128-99-7/Angiotensin II; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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