Document Detail

Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities.
MedLine Citation:
PMID:  3433304     Owner:  NLM     Status:  MEDLINE    
Aristolochic acid, an alkaloid from the plant Aristolochia species, interacts with the major basic phospholipase A2 from Vipera russelli venom. It is an uncompetitive inhibitor with a Ki of 9.9 X 10(-4)M when phosphatidylcholine is used as substrate. The inhibition of direct and indirect hemolysis is higher compared to the inhibition of phosphatidylcholine hydrolysis. Edema-inducing activity of Vipera russelli phospholipase A2 is inhibited by aristolochic acid when injected either as a mixture or separately. Both i.m. and i.p. administration of aristolochic acid following phospholipase injection are equally effective in inhibiting edema. The alkaloid inhibits the edema-inducing activity as soon as it reaches the site, but does not aid in recovery. Aristolochic acid failed to inhibit other pathological activities of the enzyme.
B S Vishwanath; T V Gowda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  25     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-03     Completed Date:  1988-03-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  929-37     Citation Subset:  IM    
Department of Biochemistry, University of Mysore, India.
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MeSH Terms
Aristolochic Acids*
Edema / chemically induced
Phenanthrenes / metabolism*
Phosphatidylcholines / metabolism
Phospholipases / antagonists & inhibitors*
Phospholipases A / antagonists & inhibitors*
Phospholipases A2
Viper Venoms / analysis*
Reg. No./Substance:
0/Aristolochic Acids; 0/Phenanthrenes; 0/Phosphatidylcholines; 0/Viper Venoms; 313-67-7/aristolochic acid I; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A; EC A2

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