| Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. | |
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MedLine Citation:
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PMID: 17634201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are peptides that act both peripherally and centrally to reduce food intake by decreasing meal size. The present study examined the effects of intraperitoneally administered bolus doses of recombinant apo AIV, CCK-8, and a combination of subthreshold doses of apo AIV and CCK on 4-h food intake in rats that were fasted overnight. Apo AIV at 100 microg/kg reduced food intake significantly relative to the saline control for 1 h, as did doses of CCK-8 at or above 0.125 microg/kg. Doses of apo AIV (50 microg/kg) or CCK (0.06 microg/kg) alone had no effect on food intake. However, when these subthreshold doses of apo AIV and CCK were administered together, the combination produced a significant inhibition of food intake relative to saline controls (P < 0.001), and the duration of the effect was longer than that caused by the administration of either apo AIV or CCK alone. The satiation effect produced by CCK-8 + apo AIV was attenuated by lorglumide, a CCK1 receptor antagonist. We conclude that, whereas the intraperitoneal administration of doses of either recombinant apo AIV or CCK at or above threshold levels reduces food intake, the coadministration of subthreshold doses of the two peptides is highly satiating and works via CCK1 receptor. |
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Authors:
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Chun Min Lo; Dian Ming Zhang; Kevin Pearson; Liyun Ma; William Sun; Randall R Sakai; W Sean Davidson; Min Liu; Helen E Raybould; Stephen C Woods; Patrick Tso |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-07-18 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 293 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-03 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1490-4 Citation Subset: IM |
Affiliation:
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Dept. of Pathology and Laboratory Medicine, Univ. of Cincinnati, 2120 E. Galbraith Rd., Cincinnati, OH 45237-0507, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism, pharmacology* Apolipoproteins A / metabolism, pharmacology* Appetite Depressants / metabolism, pharmacology* Dose-Response Relationship, Drug Feeding Behavior / drug effects, physiology* Hormone Antagonists / pharmacology Intestine, Small / metabolism Male Proglumide / analogs & derivatives, pharmacology Rats Rats, Sprague-Dawley Sincalide / metabolism, pharmacology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK-17844/DK/NIDDK NIH HHS; DK-38180/DK/NIDDK NIH HHS; DK-56910/DK/NIDDK NIH HHS; DK-63907/DK/NIDDK NIH HHS; DK-76928/DK/NIDDK NIH HHS; ES-14464/ES/NIEHS NIH HHS; HL-82734/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Apolipoproteins A; 0/Appetite Depressants; 0/Hormone Antagonists; 0/apolipoprotein A-IV; 25126-32-3/Sincalide; 6620-60-6/Proglumide; 97964-56-2/lorglumide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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