| Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | |
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MedLine Citation:
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PMID: 17900911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that effect gene regulation. To know the interaction of aliphatic cap groups with HDACs, cyclic tetrapeptide and bicyclic peptide disulfide hybrids were synthesized without aromatic ring in their macrocyclic framework. Benzene ring of l-Phe in chlamydocin was replaced with several aliphatic amino acids and also a fused bicyclic tetrapeptide was synthesized by ring closing metathesis using Grubb's first generation catalyst. The inhibitory activities of the cyclic peptides against histone deacetylase enzymes were evaluated, which demonstrated most of them are interesting candidates as anticancer agents. |
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Authors:
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Norikazu Nishino; Gururaj M Shivashimpi; Preeti B Soni; Mohammed P I Bhuiyan; Tamaki Kato; Satoko Maeda; Tomonori G Nishino; Minoru Yoshida |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-15 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 16 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-01-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 437-45 Citation Subset: IM |
Affiliation:
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Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan. nishino@life.kyutech.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis Cell Line Enzyme Inhibitors / chemical synthesis, pharmacology Histone Deacetylase 1 Histone Deacetylase Inhibitors* Humans Inhibitory Concentration 50 Peptides, Cyclic / chemical synthesis*, pharmacology* Repressor Proteins Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Peptides, Cyclic; 0/Repressor Proteins; EC 3.5.1.98/HDAC1 protein, human; EC 3.5.1.98/HDAC4 protein, human; EC 3.5.1.98/HDAC6 protein, human; EC 3.5.1.98/Histone Deacetylase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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