Document Detail

Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response.
MedLine Citation:
PMID:  21368747     Owner:  NLM     Status:  MEDLINE    
There has been significant controversy whether stressful life events (SLEs) experienced over the lifespan may elevate the risk of depression in individuals who are homozygous for the short (S) allele of the repeat length polymorphism (5-HTTLPR) in the regulatory region of the serotonin transporter gene (SLC6A4), compared with individuals homozygous for the long (L) allele. On the basis of the hypothesis that age may be a critical variable, by which such a gene-by-environment interaction may be present in younger adults, but not in older adults and in children, aim of this study was to investigate the role of 5-HTTLPR and SLEs on the endocrine stress response in multiple age cohorts. A total of 115 children (8-12 years), 106 younger adults (18-31 years), and 99 older adults (54-68 years) were subjected to the Trier Social Stress Test (TSST) and structured interviews on SLEs. The TSST induced significant endocrine stress responses in all groups. There was a main effect of genotype in younger and older adults with individuals homozygous for the more active L allele showing a significantly larger cortisol response to the TSST than individuals carrying at least one of the low-expressing S alleles. As predicted, there was a significant interaction of 5-HTTLPR genotype and SLEs, but this interaction was only significant in younger adults and only when the measured SLEs had occurred during the first 5 years of life, suggesting that both age and the specific type of SLE has a role in whether a significant gene-environment interaction is observed.
Anett Mueller; Diana Armbruster; Dirk A Moser; Turhan Canli; Klaus-Peter Lesch; Burkhard Brocke; Clemens Kirschbaum
Related Documents :
20629497 - Auxological and metabolic study in small for gestational age children during 2 years fo...
14988637 - The biagram vector: a graphical relation between reactance and phase angle measured by ...
20329667 - Postnatal development of the human hippocampal formation.
15232777 - Is manual foot lenght measurement of comparable value to ultrasound femur and humerus m...
16906087 - Mechanical effects of partial sacrectomy: when is reconstruction necessary?
16403997 - The effects of loading and unloading treadmill walking on balance, gait, fall risk, and...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-03-02
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  36     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-13     Completed Date:  2011-08-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1332-9     Citation Subset:  IM    
Department of Psychology, Stony Brook University, Stony Brook, NY 11794-2500, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Analysis of Variance
Genome-Wide Association Study
Hydrocortisone / blood*
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Predictive Value of Tests
Serotonin Plasma Membrane Transport Proteins / genetics*
Stress, Psychological / genetics*,  metabolism*
Young Adult
Grant Support
1 R01 AG034578-01/AG/NIA NIH HHS
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peroxisome proliferator-activated receptor-? is renoprotective in doxorubicin-induced glomerular inj...
Next Document:  Selective ?4?2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GA...