Document Detail


Interaction of Lactobacillus fermentum BGHI14 with rat colonic mucosa -- implications for colitis induction.
MedLine Citation:
PMID:  23851097     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present study was carried out to test colonic mucosal response of rats to oral supplementation of Lactobacillus fermentum BGHI14 and to correlate the tissue reaction to TNBS-colitis induction with mucosal barrier alterations caused by bacterial ingestion. Immune cell-mediated reaction of healthy colonic tissue was noticed after bacterial feeding. After prolonged bacterial treatment, the observed reaction had retreated to normality but mRNA levels of proinflammatory cytokines IL-1β and TNF-α remained elevated. These data point to the chronic low grade inflammation that could be caused by long-term probiotic consumption. Although no detrimental effects of bacterial pretreatment was noticed in colitic rats, at least in acute state of disease,results obtained in our study point to the necessity of reassesment of existing data on safety of probiotic preparations. Additionaly, probiotic effects in experimental colitis models might depend on time-coordination of disease induction with treatment duration.
Authors:
Jovanka Lukic; Ivana Strahinic; Marina Milenkovic; Natasa Golic; Milan Kojic; Ljubisa Topisirovic; Jelena Begovic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-12
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  -     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, VojvodeStepe 444/a, P.O. Box 23, 11010 Belgrade, Serbia.
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