| Interaction of L-gamma-glutamyl-alpha,beta-dehydroamino acids with gamma-glutamyl transpeptidase. | |
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MedLine Citation:
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PMID: 11126002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three gamma-glutamyl alpha,beta-dehydroamino acids: L-gamma-glutamyl-dehydroalanine, L-gamma-glutamyl-(Z)-dehydrobutyrine and L-gamma-glutamyl-(E)-dehydrobutyrine have been prepared as potential ligands (inhibitors or substrates) for gamma-glutamyl transpeptidase (GGT). Both isomers of gamma-glutamyl-dehydrobutyrines proved to be inhibitors of GGT, slightly better than the saturated analogue, L-gamma-glutamyl-L-butyrine. However, their solvolysis catalysed by the enzyme is slower than that of the latter. L-gamma-Glutamyl-(E)-dehydrobutyrine seems to be a more active compound in both enzymatic tests. L-gamma-Glutamyl-dehydroalanine elicited only low inhibitory activity and, moreover, was unstable under conditions of the solvolysis test. |
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Authors:
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Z Kubica; B Rzeszotarska; K Midura-Nowaczek; W Roszkowska-Jakimiec |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 55 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-27 Completed Date: 2001-03-01 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 841-4 Citation Subset: IM |
Affiliation:
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Department of Organic Chemistry, University of Opole, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme Inhibitors
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chemical synthesis*,
pharmacology Solvents gamma-Glutamyltransferase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Solvents; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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