| Interaction of fluorescently substituted metallacarboranes with cyclodextrins and phospholipid bilayers: fluorescence and light scattering study. | |
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MedLine Citation:
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PMID: 20085334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We prepared two fluorescein-[3-cobalt(III) bis(1,2-dicarbollide)](-) conjugates. They are sparingly soluble in water and form large aggregates in aqueous solutions. An extensive study on their spectral and aggregation behavior was carried out. To prepare their well-defined dispersion in aqueous systems, we studied the interaction of both probes with two biocompatible amphiphilic systems, cyclodextrins, which are frequently used in drug-delivery systems, and phospholipid membranes, which are the major constituents of cell barriers in living organisms. The presence of fluorescein in both conjugates allows us to study their behavior in detail by steady-state and time-resolved fluorometry, fluorescence correlation spectroscopy, and fluorescence lifetime imaging. The self-assembly of these metallacarboranes in aqueous solutions was studied by dynamic light scattering. The study shows that the compounds interact with cyclodextrins that increases their solubility in water, and they solubilize easily in phospholipid bilayers. |
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Authors:
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Mariusz Uchman; Piotr Jurkiewicz; Petr Cígler; Bohumír Grüner; Martin Hof; Karel Procházka; Pavel Matejícek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 26 ISSN: 1520-5827 ISO Abbreviation: Langmuir Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 6268-75 Citation Subset: IM |
Affiliation:
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Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 40 Prague 2, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane
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metabolism Cyclodextrins / metabolism* Fluorescent Dyes / chemistry, metabolism* Light* Lipid Bilayers / metabolism* Models, Molecular Molecular Conformation Organometallic Compounds / chemistry, metabolism* Phospholipids / metabolism* Scattering, Radiation* Spectrometry, Fluorescence Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Fluorescent Dyes; 0/Lipid Bilayers; 0/Organometallic Compounds; 0/Phospholipids; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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