Document Detail


Interaction of dopamine transporter gene and observed parenting behaviors on attention-deficit/hyperactivity disorder: a structural equation modeling approach.
MedLine Citation:
PMID:  23153115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emerging evidence suggests that some individuals may be simultaneously more responsive to the effects from environmental adversity and enrichment (i.e., differential susceptibility). Given that parenting behavior and a variable number tandem repeat polymorphism in the 3'untranslated region of the dopamine transporter (DAT1) gene are each independently associated with attention-deficit/hyperactivity disorder (ADHD), our goal was to evaluate the potential interactive effects of child DAT1 genotype with positive and negative parenting behaviors on childhood ADHD. We recruited an ethnically diverse sample of 150 six- to nine-year-old boys and girls with and without ADHD. Children were genotyped for a common polymorphism of the DAT1 gene, and objective counts of observed parenting behavior (i.e., negativity and praise) were obtained from a valid parent-child interaction task. Structural equation modeling was used to examine the interactive effects of DAT1 and observed parenting with a latent ADHD factor. We detected a significant interaction between observed praise and child DAT1 (coded additively), which suggested that praise was associated with increased ADHD, but only among youth with the 9/10 genotype. In addition, a marginally significant interaction between DAT1 (coded additively and recessively) and observed negativity emerged for ADHD, such that negativity was positively associated with ADHD but only for youth with the 9/9 genotype. Although differential susceptibility theory was not fully supported, these preliminary results suggest that interactive exchanges between parenting behavior and child genotype potentially contribute to the development of ADHD. Clinical implications for interactions between parenting behavior and child genotype are discussed.
Authors:
James J Li; Steve S Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-15
Journal Detail:
Title:  Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53     Volume:  42     ISSN:  1537-4424     ISO Abbreviation:  J Clin Child Adolesc Psychol     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-16     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101133858     Medline TA:  J Clin Child Adolesc Psychol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-86     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Attention
Attention Deficit Disorder with Hyperactivity / genetics*,  psychology*
Child
Dopamine Plasma Membrane Transport Proteins / genetics*
Female
Gene-Environment Interaction
Genotype
Humans
Male
Minisatellite Repeats
Parent-Child Relations
Parenting / psychology*
Grant Support
ID/Acronym/Agency:
RL1 DA024853/DA/NIDA NIH HHS; RL1DA024853/DA/NIDA NIH HHS; UL1 DE019580/DE/NIDCR NIH HHS; UL1-DE019580/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins
Comments/Corrections

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