Document Detail


Interaction of Cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxy glucose uptake in 3T3-L1 adipocytes.
MedLine Citation:
PMID:  21870829     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydroxycinnamic acid derivatives are naturally occurring substances found in fruits, vegetables, and flowers and are consumed as dietary phenolic compounds. The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin, on the uptake of 2-deoxy glucose (2DG) by 3T3-L1 adipocytes is studied. All the phytochemicals other than cinnamic acid show synergistic interaction in 2DG uptake with both the OHDs. THZ (20μM) in combination with ferulic acid (25μM) or p-coumaric acid (25μM) increases the 2DG uptake by 7 or 6.34-folds respectively with respect to control. Whereas, metformin (20μM) along with ferulic acid (25μM) or cinnamic acid (25μM) increases 2DG uptake by 6.45 or 5.87-folds respectively when compared to control. Chlorogenic and cinnamic acids increased the expression of PPARγ whereas other hydroxycinnamic acid enhanced the expression of PI3K, indicating different mechanism of action between these compounds. These phytochemicals were able to reduce the expressions of the fatty acid synthase and HMG CoA reductase genes indicating that they may be able to reduce the secondary complications caused because of the accumulation of lipids. These studies suggest that hydroxycinnamic acid derivatives may be beneficial for the treatment of diabetes mellitus. They may act as a supplement with commercial drug and may reduce the secondary complications caused by OHDs.
Authors:
Pranav Kumar Prabhakar; Mukesh Doble
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-26
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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