| Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum. | |
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MedLine Citation:
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PMID: 23338155 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The objective of this study was to compare the expression levels of interleukin (IL)-17 IL-17 and IL-23 in serum from patients with both oral lichen planus and chronic periodontitis (OLP-CP), patients only with oral lichen planus (OLP), patients only with chronic periodontitis (CP), and healthy controls (HC). The serum samples were collected from 35 OLP-CP patients, 35 OLP patients, 30 CP patients, and 30 healthy controls. ELISA test was used to detect expression levels of IL-17 and IL-23 in serum from these four groups. ELISA analysis showed significantly elevated levels of serum IL-17 in OLP-CP group compared with OLP group (P < 0.05) and HC group (P < 0.01). Serum IL-23 result showed that there was an increased expression level in OLP-CP compared with HC group (P < 0.01). Additionally, female OLP-CP group showed elevated level of serum IL-17 compared with female OLP group, and also erosive OLP-CP group demonstrated increased serum IL-17 level compared with erosive OLP group. Moreover, analysis showed positive significant correlations of serum IL-17 level with probing depth (P < 0.05) and plaque index (P < 0.05) in erosive OLP-CP patients. This study indicates that OLP-CP patients get higher expression level of serum IL-17 and had susceptibility to erosive or female subtype, which indicated that IL-17 may participate in the disease immunopathogenesis of both common oral diseases. |
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Authors:
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Hui Wang; Zhenhua Luo; Lei Lei; Zheng Sun; Min Zhou; Hongxia Dan; Xin Zeng; Qianming Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: Inflammation Volume: - ISSN: 1573-2576 ISO Abbreviation: Inflammation Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600105 Medline TA: Inflammation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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